Environmental and Genetic Drivers of Developmental Health: Toxicological Mechanisms and Integrative Therapeutic Strategies

The paradigm of modern public health is shifting toward a multi-dimensional understanding of how environmental and genetic factors interact to shape human health. This shift is particularly significant during critical developmental windows, during which exposure to environmental stressors, including industrial chemicals, endocrine disruptors, and lifestyle-related toxins, can trigger profound physiological changes. Such exposures interfere with key molecular pathways, ultimately leading to altered physiological outcomes.These interactions often manifest as complex molecular disruptions, such as altered inflammatory signaling, mitochondrial dysfunction, and epigenetic reprogramming, which can predispose individuals to chronic diseases later in life. Furthermore, the clinical manifestation of inherited metabolic disorders underscores the vital role of early-life screening and genetic surveillance in preventing long-term disability. However, understanding these pathways is only the first step. As toxicology evolves, there is an increasing need to explore how cutting-edge biotechnologies, including regenerative medicine and exosome-based therapies, can offer novel preventive and therapeutic solutions. This Research Topic seeks to explore this nexus, emphasizing that protecting population health requires a holistic view encompassing environmental monitoring, genetic risk assessment, and the development of innovative, multi-targeted therapeutic interventions to enhance resilience against environmental challenges.The goal of this Research Topic is to bring together interdisciplinary contributions that advance our understanding of how environmental and biological factors shape health during early development, and to identify strategies for prevention, early diagnosis, and intervention. We aim to create a forum that integrates population-level surveillance, mechanistic toxicology, and innovative therapeutics, thereby addressing the critical gap between identifying developmental health threats and implementing effective solutions. By fostering collaboration across disciplines, this collection seeks to generate insights that can inform risk assessment, guide clinical management, and support evidence-based public health policies. Ultimately, we aspire to provide a translational framework that promotes resilience and improves long-term health outcomes for the most vulnerable populations, including the developing fetus, infant, and child.We invite original research, systematic reviews, and meta-analyses that contribute to our understanding of the toxicological and genetic underpinnings of health and disease. The scope of this Research Topic includes, but is not limited to:• Mechanistic Developmental Toxicology: Studies on how early-life exposure to environmental pollutants affects organ development and long-term physiological function.• Genetic Susceptibility and Screening: Research on the identification of pathogenic genes, population-level screening for metabolic disorders, and gene–environment interactions.• Inflammatory and Oxidative Pathways: Investigation of the molecular drivers of injury, such as inflammasome activation, oxidative stress, and impaired mitophagy.• Innovative Interventions: Development and validation of novel therapies, including stem cell-derived products, nanomedicine, and bioelectronic medicine such as acupuncture, within a toxicological context.• Mitochondrial Health: The role of mitochondrial dynamics and metabolic homeostasis in responding to environmental and genetic stressors.• Translational Public Health: Studies focusing on translating bench-side findings into community-based prevention and clinical treatment strategies. Topic editors: Guohui Sun, Chengwei He, Jianhua Wang Source: https://www.frontiersin.org/research-topics/82693/environmental-and-genetic-drivers-of-developmental-health-toxicological-mechanisms-and-integrative-therapeutic-strategies