From Fat Pad to Active Organ: Epicardial Fat’s Role in Cardiac Health and Disease

Epicardial fat, a distinctive visceral adipose tissue depot located between the myocardium and the visceral layer of the pericardium, has gained recognition as a vital contributor to cardiovascular disease pathophysiology. Previously considered an inert fat pad, epicardial adipose tissue (EAT) is now understood to be a dynamic, metabolically active organ exerting paracrine and vasocrine effects on cardiac function and coronary health. Research has underscored its involvement in processes such as inflammation, atherogenesis, myocardial remodeling, arrhythmogenesis, and overall cardiometabolic risk. The burgeoning evidence connecting EAT's volume and activity to adverse cardiac outcomes necessitates a more profound comprehension of its biological mechanisms, clinical implications, diagnostic assessments, and potential therapeutic strategies.This Research Topic aims to deliver an advanced overview of the role of epicardial fat in cardiovascular health and disease. We invite contributions from original research articles, translational studies, systematic reviews, meta-analyses, imaging studies, clinical trials, and expert opinions, covering the extensive scope of epicardial fat-related research.Core areas of interest include, but are not limited to:o Pathophysiological Mechanisms: Detailed exploration of the molecular biology of epicardial fat, including adipokine secretion, inflammatory pathways, and its effects on the myocardium and coronary arteries.o Imaging and Quantification: Progress in echocardiography, cardiac CT, MRI, and other modalities for assessing EAT and the prognostic value of these different techniques.o Clinical Associations: Investigating the links between EAT and conditions such as coronary artery disease, atrial fibrillation, heart failure, and related cardiac or metabolic disorders.o Therapeutic Strategies: Examination of lifestyle modifications, pharmacological approaches, and innovative therapies aimed at reducing EAT volume or modulating its activity.o Emerging Research and Future Perspectives: Identification of novel biomarkers, genetic markers, and personalized medicine approaches targeting epicardial fat.The overall aim is to enhance understanding of epicardial fat as a critical biomarker and therapeutic target in cardiovascular medicine, promoting multidisciplinary research and innovation to advance patient care. Topic editors: Khanh-Van Tran, Christos Kourek Source: https://www.frontiersin.org/research-topics/75097/from-fat-pad-to-active-organ-epicardial-fats-role-in-cardiac-health-and-disease