From Microglia to Maladaptation: Cellular Cascades in Neuroinflammatory Brain Injury

Neuroinflammation is a key driver of diverse brain pathologies, from neurodegeneration and trauma to infection and psychiatric disorders yet its protective and damaging roles remain difficult to disentangle. This special issue seeks concise, high quality contributions that clarify how inflammatory signaling and glial activation translate into defined structural and functional changes in the brain, and how these processes can be targeted for diagnosis or therapy. The goal is to bring together mechanistic and translational studies that link microglial and astrocytic states, cytokines and chemokines, inflammasomes, and blood-brain-barrier dysfunction, synaptic loss, protein glycosylation and cell surface signaling. Submissions using advanced imaging, omics, human tissue or well characterized models to map these inflammation pathology relationships as well as work probing interactions with systemic inflammation, vascular injury or the gut brain axis, are particularly encouraged.Authors are invited to submit original articles, reviews, short communications, case reports, commentaries and perspectives that explicitly connect inflammatory mechanisms with brain pathology across disease and lifespan. Manuscripts should be written in clear, accessible English, follow the journal's formatting and ethical guidelines with full submission instructions available on the journal website. Topic editors: Adnan Akif, Rashu Barua, MD OBAYED RAIHAN, Md Nabiul Islam Source: https://www.ebm-journal.org/research-topics/46/from-microglia-to-maladaptation-cellular-cascades-in-neuroinflammatory-brain-injury