Functional Biomaterial Interfaces for Biomedical Sensing, Regeneration, and Therapeutic Applications

Advances in functional biomaterial interfaces are creating new opportunities for biomedical applications that require controlled interactions with biological environments. In this context, engineered surfaces, bioactive coatings, polymeric and composite biomaterials, electroactive materials, and hybrid biointerfaces play a key role in improving biocompatibility, biological stability, antimicrobial response, sensing performance, and tissue-regenerative potential. The integration of materials science, surface engineering, microbiology, and in vitro biological evaluation is essential for designing biomaterial-based platforms with reliable performance under physiological or simulated biological conditions.Despite significant progress, important challenges remain in the translation of functional biomaterial interfaces toward biomedical use. Issues such as biofouling, poor long-term stability, limited biocompatibility, weak coating adhesion, inadequate antimicrobial response, insufficient bioactivity, and variable performance in biological media continue to restrict their practical application. In addition, the reproducible fabrication of functional coatings, polymeric composites, and hybrid biomaterial systems remains a critical requirement for ensuring consistent biological, therapeutic, and sensing-related performance.Recent developments in bioactive and antimicrobial coatings, nanostructured biomaterials, polymer-based composites, electroactive interfaces, and surface-functionalized materials offer promising strategies to address these limitations. These approaches are relevant not only for biomedical sensing and diagnostic platforms, but also for regenerative medicine, bone tissue engineering, localized therapeutic response, and biologically active implant surfaces. However, further work is needed to understand how material composition, surface chemistry, microstructure, degradation behavior, and biological interactions influence functional performance.Therefore, this Research Topic focuses on studies that connect biomaterial design, surface/interface engineering, sensing capability, regenerative potential, therapeutic response, microbiological behavior, and in vitro validation. The scope is centered on functional biomaterial interfaces, with particular interest in systems designed for biomedical sensing, tissue regeneration, antimicrobial activity, and therapeutic interaction with biological environments.This Research Topic aims to bring together cutting-edge studies on the design, fabrication, characterization, and biological evaluation of functional biomaterials, coatings, composites, and biointerfaces for biomedical applications. We welcome interdisciplinary contributions focused on bioactive and antimicrobial coatings, polymeric and composite biomaterials, electroactive and nanostructured interfaces, biomaterials for bone regeneration, therapeutic biointerfaces, and in vitro models for validating biological and functional performance. Topics of interest include, but are not limited to:o Functional biomaterial interfaces for biomedical sensing and diagnostic applicationso Bioactive coatings and biomaterials for bone regeneration and tissue engineeringo Antimicrobial biomaterials, coatings, and surfaces for biomedical useo Polymeric, composite, and hybrid biomaterials for biological interaction and functional performanceo Electroactive and nanostructured biomaterials for sensing, stimulation, or therapeutic responseo Surface engineering strategies to improve biocompatibility, bioactivity, antifouling behavior, and biological stabilityo In vitro evaluation of biomaterials, coatings, and biointerfaces under simulated biological conditionso Microbiological assessment of antimicrobial biomaterials and functional surfaceso Structure–property–function relationships in coatings, composites, and biomaterial interfaceso Reproducible fabrication and characterization of functional biomaterial interfaces for biomedical applications Topic editors: John Henao, Piergiorgio Gentile, Astrid Lorena Giraldo B, Joel Girón-Hernández Source: https://www.frontiersin.org/research-topics/80750/functional-biomaterial-interfaces-for-biomedical-sensing-regeneration-and-therapeutic-applications