Future of Miniaturized Biosensors: Real-Time Oxidative Stress Monitoring

The field of biosensor technology is undergoing rapid transformation, driven by the need for precise, real-time monitoring of biochemical processes such as oxidative stress in both clinical and environmental contexts. Oxidative stress—arising from an imbalance between reactive oxygen species and antioxidant defenses—plays a pivotal role in the onset and progression of numerous chronic diseases, as well as ecological disturbances. Traditional methods for detecting oxidative stress markers often require laborious sample processing and provide limited temporal and spatial resolution, leaving a gap in continuous and minimally invasive analysis. Recent breakthroughs have seen the use of advanced nanomaterials, such as nanosheets and hybrid nanostructures, coupled with innovative energy-harvesting methods, laying the groundwork for highly integrated, miniaturized biosensors that could revolutionize health diagnostics and environmental monitoring.Amid these developments, the central question remains: how can we design biosensors that are small, stable, highly sensitive, real-time, and suitable for wearable or implantable formats? Emerging studies indicate that nanosheet-based frameworks, hybrid biofuel cell systems, and interdisciplinary approaches combining material science, bioengineering, and informatics could address these challenges. Notable progress has been achieved in the fabrication of multiplexed platforms capable of detecting low-abundance markers with high accuracy, alongside advances in wireless data transmission and machine-learning-driven data interpretation. Despite these achievements, critical gaps persist in the areas of long-term sensor stability, user-friendly data visualization, power efficiency, sustainable manufacturing, and seamless integration into everyday life. The need persists for fresh investigations into scalable fabrication processes, biocompatibility, and the accurate, real-time analysis of oxidative stress in diverse settings.This Research Topic aims to catalyze innovation in the development of miniaturized biosensors for oxidative stress, with an emphasis on real-time, reliable detection and practical applicability in health and environmental sectors. The objective is to foster interdisciplinary research that bridges engineering, nanoscience, and data analytics, seeking solutions for current technological limitations, and exploring pathways to sustainable and impactful biosensing technologies. Key questions include the optimization of sensor architecture, integration with wearable/implantable systems, enhancement of data analysis pipelines, and the alignment of sensor platforms with sustainable development goals.To gather further insights in the future trajectories and practical limitations of miniaturized oxidative stress biosensors, we welcome articles addressing, but not limited to, the following themes:- Design and fabrication of next-generation miniaturized and nanoscale biosensors for oxidative stress markers- Nanosheet-based frameworks and hybrid biofuel cells in wearable and implantable devices- Algorithms, data analysis, and visualization workflows for real-time oxidative stress monitoring- Biocompatibility, stability, and user integration challenges of miniaturized biosensors- Applications in personalized medicine, environmental surveillance, and global health initiatives- Approaches toward sustainable development and scalable manufacturing of biosensor technologies Topic editors: Marcela Cecilia Rodríguez, M. Gabriela Almeida Source: https://www.frontiersin.org/research-topics/77382/future-of-miniaturized-biosensors-real-time-oxidative-stress-monitoring