Gut dysbiosis and the gut-liver-brain axis in neuroimmune pathology

The intestinal mucosal barrier is a critical checkpoint between the gut microbiota and the host immune system. When barrier integrity fails, whether through Paneth cell dysfunction, dysbiosis, increased intestinal permeability (leaky gut), or other insults, microbial products and metabolites can translocate into the portal circulation, triggering hepatic immune activation and driving a systemic inflammatory response. A growing body of evidence suggests this hepatic inflammatory response does not stop at the liver. cytokine and metabolite signaling can propagate further along a gut-liver-brain axis, contributing to neuroinflammatory and neuroimmune outcomes. This axis appears particularly consequential in neonatal and pediatric populations, where the gut microbiome, immune system, and nervous system are all still developing and may be more vulnerable to early disruption.This Research Topic aims to take a systems-level view of how mucosal barrier breakdown, including leaky gut, and gut dysbiosis propagate through the gut-liver-brain axis to drive systemic and neuroimmune pathology. Rather than treating gut, liver, and brain effects as separate fields, the goal is to trace the same upstream mechanism, microbial translocation and barrier failure, through each downstream compartment, connecting local intestinal inflammation to systemic inflammatory response and further to hepatic signaling and central nervous system immune activation. We are especially interested in work addressing developmental and neonatal vulnerability along this axis, given its relevance to early-life disease risk, and we particularly encourage submissions from researchers studying leaky gut as a driver of systemic inflammation. By assembling mechanistic, translational, and clinical perspectives in one collection, we hope to advance understanding of how early barrier and microbiome disruption shapes long-term neuroimmune outcomes, and to identify points along the axis where intervention could be most effective.We welcome Original Research, Reviews, Mini Reviews, and Case Reports addressing: mechanisms of mucosal barrier integrity, leaky gut, and microbial translocation as drivers of local intestinal inflammation and the broader gut-liver-brain axis; cytokine and metabolite signaling connecting intestinal and hepatic inflammation to central nervous system immune activation; developmental and neonatal or pediatric vulnerability of this axis; and therapeutic or dietary strategies, including probiotics and barrier-protective agents, targeting the axis at any of its points (gut, liver, or brain). Studies integrating clinical, translational, and basic immunology perspectives across this axis are particularly encouraged, as are submissions from experts specifically focused on leaky gut as an inflammatory trigger. Topic editors: PRADEEP KUMAR SHUKLA, Mohammad Moshahid Khan, Dr. Avtar Singh Meena Source: https://www.frontiersin.org/research-topics/85894/gut-dysbiosis-and-the-gut-liver-brain-axis-in-neuroimmune-pathology