Gut Microbiota-Derived Metabolites in Redox–Inflammatory Crosstalk: Mechanisms and Therapeutic Opportunities Across Human Diseases

The gut microbiota is increasingly recognized as a central regulator of host homeostasis and disease susceptibility. Beyond changes in microbial composition, functional alterations in the gut microbiome can influence host physiology through microbial metabolites, microbial structural components, and microbe–host signaling pathways. Among the major downstream consequences of dysbiosis, oxidative stress and persistent inflammatory activation frequently coexist and reinforce one another, contributing to epithelial barrier dysfunction, metabolic disturbances, immune dysregulation, and tissue injury. However, the mechanistic links connecting microbial alterations to redox imbalance and inflammatory signaling across different organ systems remain incompletely understood.This Research Topic aims to advance understanding of how gut microbiota and microbiota-derived metabolites shape the redox–inflammatory microenvironment in human disease. Particular emphasis will be placed on studies that move beyond descriptive associations and provide mechanistic, functional, or translational evidence linking specific microbial taxa, microbial functions, or metabolites to oxidative stress, antioxidant defenses, innate and adaptive immune responses, and downstream organ injury. We are also interested in the bidirectional nature of these interactions, including how oxidative and inflammatory conditions within the host can remodel microbial communities and microbial metabolism.By integrating microbiology, redox biology, immunology, metabolomics, and translational medicine, this collection seeks to define common and disease-specific mechanisms of microbiota–host crosstalk and to identify microbiome-associated biomarkers and therapeutic targets. Studies addressing gut–organ axes, including the gut–liver, gut–kidney, gut–brain, gut–lung, gut–heart, and gut–metabolic axes, are particularly encouraged.We welcome Original Research, Reviews, Mini Reviews, Systematic Reviews, Methods, Perspectives, and other relevant article types addressing, but not limited to:• Microbial and metabolic drivers of host oxidative stress and inflammatory signaling;• Microbiota-derived metabolites that modulate reactive oxygen species, antioxidant pathways, inflammasomes, cytokine networks, and immune-cell function;• Interactions among dysbiosis, intestinal barrier dysfunction, microbial translocation, oxidative stress, and systemic inflammation;• Gut microbiota–redox–inflammation crosstalk in metabolic, cardiovascular, renal, neurological, respiratory, immune-mediated, and other human diseases;• Multi-omics and systems-level approaches for identifying microbiome–metabolite–host signaling networks;• Microbiome-targeted interventions, including diet, prebiotics, probiotics, postbiotics, fecal microbiota transplantation, and metabolite-based strategies.To maintain a clear microbiological focus, studies centered exclusively on host oxidative stress or inflammation without a defined microbiota, microbial-function, or microbial-metabolite component would fall outside the primary scope of this Research Topic. Topic editors: Yunhe Xiong, Ming Xiao, Yuqi Xia Source: https://www.frontiersin.org/research-topics/86626/gut-microbiota-derived-metabolites-in-redox-inflammatory-crosstalk-mechanisms-and-therapeutic-opportunities-across-human-diseases