Gut Microbiota in Obesity: Mechanisms, Metabolic Interactions, and Therapeutic Strategies

Obesity remains one of the most pressing global public health concerns, driven by complex interactions between genetic, environmental, and behavioral factors. In recent years, mounting evidence has revealed that gut microbiota composition and function play a critical role in regulating metabolic homeostasis, energy balance, and adiposity. Dysbiosis is increasingly recognized as both a driver and a consequence of obesity, contributing to low-grade inflammation, altered bile acid metabolism, and impaired nutrient signaling pathways. However, despite significant advances, the exact mechanisms linking microbial alterations to obesity pathogenesis remain incompletely understood. Questions persist regarding causality, host-specific variations, and the influence of diet, medications, and lifestyle factors on gut microbial ecology.This Research Topic aims to consolidate and advance understanding of the mechanistic, metabolic, and therapeutic dimensions of gut microbiota in obesity. By integrating findings from multi-omics studies, clinical interventions, and computational modeling, this collection seeks to uncover causal pathways, highlight microbiome-derived biomarkers, and evaluate evidence-based microbial and nutritional interventions. It also aims to promote translational advances in personalized and precision medicine, bridging experimental insights to real-world clinical and public health applications.To gather further insights into the multifaceted links between the gut microbiome and obesity, we welcome contributions addressing, but not limited to, the following themes:- Gut-brain axis and appetite regulation in obesity- Multi-omics approaches in microbiome research Probiotics, prebiotics, and nutraceutical interventions- Personalized therapeutics and host-microbiome interactions- Microbial metabolites, bile acids, and endocrine signaling- Systems biology and computational modeling in obesity research- Clinical trials and translational studies targeting microbiome modulationWe welcome original research, systematic reviews, clinical trials, and meta-analyses contributing to this growing field. Topic editors: Dr. Waikhom Somraj Singh, Kuntal Manna, ARIJIT GHOSH Source: https://www.frontiersin.org/research-topics/85505/gut-microbiota-in-obesity-mechanisms-metabolic-interactions-and-therapeutic-strategies