Gut-Skin Axis and The Skin Microbiome

The intersection between nutrition and dermatology represents a dynamic and rapidly evolving field. Skin, as a metabolically active organ, reflects both systemic and local nutritional states, serving as a critical marker of homeostasis and disease. Over recent decades, research has revealed that dietary factors, including macro- and micronutrients, antioxidants, fatty acids, and gut-derived metabolites, play fundamental roles in maintaining skin integrity, modulating inflammation, and influencing immune responses. Nutritional imbalances are associated with conditions such as acne, psoriasis, atopic dermatitis, and photoaging, yet our understanding of their mechanistic underpinnings remains incomplete. Current evidence highlights contradictory findings regarding specific dietary interventions, arising from methodological differences, population variability, and limited mechanistic studies that bridge clinical and molecular data.Recent advances in dermatological science, systems biology, and metabolomics have opened new avenues for delineating the nutrition–skin connection. Studies have identified unique nutrient-related biomarkers linked to oxidative stress, microbial composition, and immune modulation in various dermatoses. Clinical trials examining the role of vitamins D and E, omega-3 fatty acids, probiotics, and restricted diets have shown promising yet inconclusive outcomes. Despite mounting evidence, there remains an urgent need to define standardized dietary recommendations, predictive biomarkers, and personalized nutritional strategies within the dermatological context. This gap underscores the necessity for interdisciplinary research that unites dermatology, nutrition science, immunology, and molecular biology.This Research Topic aims to elucidate how nutritional factors shape skin physiology and pathology, and to explore innovative nutritional interventions that may prevent or ameliorate dermatological diseases. It seeks to integrate molecular mechanisms, clinical data, and translational approaches to clarify cause–effect relationships between dietary components and skin health. The ultimate objective is to establish a robust evidence base that can support patient-tailored dietary guidelines and novel therapeutic designs. Contributions that investigate both preventive nutrition and interventional therapies are particularly welcome, as are studies emphasizing the interaction between diet, the gut–skin axis, and systemic metabolic states.To gather further insights within the field of dermatology and nutritional sciences, we welcome articles addressing, but not limited to, the following themes:- Nutritional modulation of inflammatory and autoimmune skin diseases- Molecular and metabolic mechanisms linking diet to skin barrier function- The gut–skin axis and the role of microbiota-derived metabolites- Clinical trials and epidemiological studies on dietary interventions in skin disorders- Nutrient deficiencies, oxidative stress, and skin aging- Personalized nutrition and nutrigenomics approaches in dermatology- Bioactive compounds and functional foods with dermatoprotective potentialArticle types welcomed include: Original Research, Review, Clinical Trial, Systematic Review, Mini Review, Hypothesis and Theory, and Perspective. Topic editors: Owen Kelly, Rahul Mehra, Vicente Navarro-Lopez Source: https://www.frontiersin.org/research-topics/82916/gut-skin-axis-and-the-skin-microbiome