Heterogeneity of Age-Related Rehabilitation Responses

Despite variations in rehabilitation responses being a widely accepted concept there has been little-to-no work that looks to address this critical public health issue. Aging is the greatest risk factor for an overwhelming majority of chronic diseases and geriatric syndromes. However, aging in and of itself is heterogeneous. An unmet need in the field of rehabilitation is defining therapeutic strategies that effectively intervene in multiple phenotypes of aging. Thus, the clinical efficacy of rehabilitation in older adults must be interpreted within the context of phenotypes of aging. Such information is vitally important to enable optimization of clinical effectiveness and overall wellness.Our objective is to identify and analyze the significant intrinsic and extrinsic factors, such as modulators, mechanisms, and biomarkers, that contribute to the variability in rehabilitation responsiveness among older adults across a range of clinically relevant conditions. Specifically, we aim to understand how these variations, influenced by a multitude of internal and external factors—including genetics, pre-existing health conditions, medication use, diet, and lifestyle—affect both positive and negative age-related clinical outcomes during rehabilitation. By characterizing these phenotypic age-related differences, we seek to refine and optimize rehabilitation strategies tailored to individual needs rather than applying a one-size-fits-all approach to cohorts.In this Research Topic, we seek to examine a broad spectrum of issues surrounding the heterogeneity of rehabilitation responses with phenotypic aging. We welcome submissions of original research, reviews (mini and systematic), hypothesis and theory, and perspective articles. For example, topics covered include, (but are not limited to) themes such as:• Anatomical, physiological, and biochemical changes in central and peripheral neural mechanisms with rehabilitation responses.• Functional role of these neural mechanistic changes in altered muscle performance, physical function, and mobility.• Physical and pharmacological interventions that act via neural mechanisms to enhance muscle performance, physical function, and mobility.• Impact of neural mechanistic changes on musculoskeletal and neuroscience domains (e.g., musculoskeletal, somatosensory, cognitive, motoric, etc.). Topic editors: Nathan Wages, Jongsang Son, Lauren Luginsland Source: https://www.frontiersin.org/research-topics/76976/heterogeneity-of-age-related-rehabilitation-responses