Host-Pathogen Interactions: Triggers, Regulators and Therapy of Inflammatory Responses

The field of infectious diseases centers on the intricate interplay between pathogens and the host immune system, which is crucial for determining disease outcomes. When an infection occurs, host cells detect microbial components via pattern recognition receptors, sparking inflammatory responses that are vital for pathogen clearance. Nonetheless, excessive or uncontrolled inflammation can result in tissue damage, chronic illness, or facilitate immune evasion by pathogens. It is essential to comprehend the molecular triggers, regulatory networks, and cellular components involved in maintaining this balance to progress in therapeutic strategies. Recent developments in immunology, genomics, and host-targeted therapies have uncovered new mechanisms that regulate inflammation during infections. However, there remains a need for further investigation into these host-pathogen dynamics to identify novel therapeutic pathways.This Research Topic aims to enhance our understanding of how host-pathogen interactions initiate, regulate, and resolve inflammatory responses during infections. The objective is to spotlight critical molecular triggers, immune regulatory mechanisms, and therapeutic targets, thereby bridging knowledge gaps concerning infection-driven inflammation. This pursuit involves integrating interdisciplinary research spanning immunology, microbiology, genomics, and therapeutic sciences to develop novel strategies that manage harmful inflammation effectively while maintaining host defense. The ultimate aim is to propel the advancement of targeted therapies that can modulate immune responses, resulting in improved outcomes for individuals with infectious and inflammation-related diseases.The scope of this Research Topic includes the exploration of complex interactions between hosts and pathogens that drive inflammatory responses during infections. We welcome submissions of original research, reviews, and perspectives on themes such as:- Identifying molecular and cellular triggers of inflammation- Understanding host immune regulatory pathways- Uncovering mechanisms of immune evasion by pathogens- Utilizing advanced methodologies such as CRISPR screening, transcriptomics, proteomics, and single-cell analysis- Developing therapeutic strategies targeting inflammatory mediators, cytokine signaling, or immune modulators to manage infection-induced inflammationThe topic invites a diverse array of studies harnessing cutting-edge tools to expand our knowledge of these dynamic interactions and contribute to the development of innovative therapeutic approaches. Topic editors: Rahul Dilawari, Vlad Alexandru Gâta, Rahul Kumar Maurya, Sudhir Kumar Source: https://www.frontiersin.org/research-topics/73441/host-pathogen-interactions-triggers-regulators-and-therapy-of-inflammatory-responses