Imaging Hypertension-Mediated Organ Damage: Quantitative Phenotyping and Multiorgan Risk Stratification

Hypertension is the leading modifiable risk factor for cardiovascular and cerebrovascular disease, yet its cumulative effects on the heart, kidneys, brain, and vasculature often remain undetected until irreversible damage occurs. This Research Topic brings together cardiology, nephrology, neurology, and imaging informatics to advance the integrated use of multimodal imaging — including echocardiography, cardiac MRI, CT, renal ultrasound and MRI, nuclear imaging, and brain MRI — for the early detection, quantitative characterization, and longitudinal monitoring of hypertension-mediated organ damage (HMOD). The issue will highlight imaging biomarkers for multiorgan risk stratification, treatment response assessment, and precision cardiovascular care, with particular emphasis on AI-assisted analysis and standardized, reproducible imaging pipelines.Modern imaging modalities — including echocardiography, cardiac magnetic resonance, computed tomography, renal ultrasound and MRI, nuclear imaging, and brain MRI — offer complementary insights into hemodynamic alterations, tissue remodeling, and microvascular dysfunction across the heart, kidneys, and brain. However, the absence of integrated analytical frameworks linking these organ systems still hampers translation into personalized prevention and treatment strategies for HMOD.This Research Topic aims to advance the integrated application of imaging techniques in the study of HMOD, promoting a holistic, multiorgan perspective on disease progression and therapy evaluation across the heart, kidneys, and brain. By uniting cardiology, nephrology, neurology, and imaging informatics, the Topic encourages interdisciplinary methodologies that bridge clinical insight with computational innovation. Contributions highlighting standardized imaging pipelines, automated quantification, or AI-assisted analysis that strengthen reproducibility and comparability across centers are particularly welcome.To gather further insights into this domain, we invite submissions addressing — but not limited to — the following themes:—Multimodal imaging biomarkers for hypertension-induced cardiac, renal, and cerebral remodeling—Renal imaging (ultrasound and MRI) for early detection of hypertensive nephropathy and microvascular kidney damage—Integrated analysis of cardiac, renal, and cerebrovascular microvascular function and tissue composition—Quantitative imaging metrics for early identification and longitudinal tracking of organ damage—Artificial intelligence and machine learning for automated feature extraction and risk prediction—Cross-organ correlations linking cardiac, renal, and cerebral structural and functional imaging endpoints—Standardization, reproducibility, and data harmonization across imaging platforms and centers—Imaging-based evaluation of antihypertensive interventions and therapeutic responses Topic editors: Lucia La Mura, Francesca Musella, Ciro Santoro Source: https://www.frontiersin.org/research-topics/83069/imaging-hypertension-mediated-organ-damage-quantitative-phenotyping-and-multiorgan-risk-stratification