Immune regulation and tolerance in tissue repair and regeneration

Tissue repair and regeneration require the immune system to do two opposing things at once: clear damage and pathogens, and tolerate the proliferating, remodeling cells that rebuild the tissue. Regulatory populations, including myeloid-derived suppressor cells, regulatory T cells, tolerogenic macrophages, and natural killer cell subsets, help create a microenvironment that permits this balance. Recent work in liver regeneration has shown that myeloid-derived suppressor cells expand after injury, interact with natural killer cells, and are linked to cellular proliferation. Similar regulatory circuits are now described in the heart, vasculature, intestine, skin, and transplanted organs. How these circuits are organized across tissues, and when they shift from supporting repair to driving fibrosis, chronic inflammation, or immune escape, remains poorly defined.This Research Topic aims to define how immune regulation and tolerance support tissue repair and regeneration across organ systems. We want to move from tissue-specific observations to shared principles, asking which regulatory cells and signals are common to regenerative contexts and which are specific to a given organ. Contributions should address how myeloid-derived suppressor cells, regulatory T cells, macrophages, natural killer cells, and other regulatory populations interact to permit proliferation and remodeling while maintaining self-tolerance. The collection also seeks to clarify how these mechanisms fail, leading to scarring, persistent inflammation, autoimmunity, graft rejection, or tumor growth. By combining global gene expression profiling, high-dimensional cytometry, and in vivo regeneration and injury models with clinical studies, we hope to reveal therapeutic strategies that promote regeneration without compromising immune homeostasis.Contributions are welcome across basic, translational, and clinical research. Themes of interest include: myeloid-derived suppressor cells and tolerogenic myeloid populations in regeneration and repair; regulatory T cells and other lymphocyte subsets in tissue healing; natural killer cell and innate lymphoid cell interactions with regulatory myeloid cells; immune tolerance in liver regeneration, cardiovascular repair, and other organ-specific regenerative contexts; transplantation and regenerative medicine, including graft acceptance; transitions from regulated repair to fibrosis, chronic inflammation, or autoimmunity; and high-dimensional profiling approaches that map immune regulation during repair. We welcome Original Research, Review, Mini Review, and Perspective articles. Topic editors: Niv Pencovich, LESLEY ANN SMYTH Source: https://www.frontiersin.org/research-topics/87466/immune-regulation-and-tolerance-in-tissue-repair-and-regeneration