Immunogenetics of inflammatory cytokine pathways in PCOS: genetic variants and adverse pregnancy outcomes

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder associated with chronic low grade inflammation, and women with PCOS face an elevated risk of adverse pregnancy outcomes, including miscarriage, preeclampsia, gestational diabetes, and preterm birth. Pro-inflammatory cytokines, notably tumor necrosis factor alpha (TNF), interleukin 6 (IL6), and interleukin 1 beta (IL1B), are central soluble mediators of immune activity at the maternal fetal interface and of endometrial receptivity. Genetic variation in these cytokine genes, particularly single nucleotide polymorphisms, can alter cytokine expression and downstream immune regulation, and may explain part of the heterogeneity in PCOS related pregnancy risk that is not captured by clinical or metabolic markers alone. This Research Topic focuses specifically on the immunogenetic architecture of inflammatory cytokine pathways in PCOS, connecting molecular genetics with the biology of soluble mediators in reproductive immune regulation.The goal of this Research Topic is to consolidate genetic and mechanistic evidence linking pro-inflammatory cytokine gene variants to cytokine expression, immune regulation, and pregnancy outcome in PCOS. We aim to bring together researchers working on cytokine genetics, soluble mediator biology, and PCOS associated pregnancy complications, to clarify how specific polymorphisms modulate cytokine expression and signaling during pregnancy, and to evaluate their potential as biomarkers for risk stratification.We welcome, but are not limited to, the following themes: -Association studies of TNF, IL6, and IL1B polymorphisms with PCOS susceptibility and severity, paired with functional validation of cytokine expression or activity-Genetic variants linked to adverse pregnancy outcomes in PCOS, including miscarriage, preeclampsia, gestational diabetes, and preterm birth-Mechanistic studies on how cytokine gene polymorphisms alter expression, immune cell signaling, or endometrial receptivity-Integration of immunogenetic and epidemiological data to identify at risk subgroups-Novel genotyping, transcriptomic, or bioinformatic approaches to map cytokine gene regulation in PCOS pregnancy, provided computational or public data analyses are accompanied by experimental validation.Manuscript Expectations: We invite Original Research, Reviews, Mini Reviews, and Systematic Reviews. Submissions should present genetic association data together with functional or mechanistic validation connecting cytokine genetics to immune regulation; studies based solely on computational analysis of public data, or purely descriptive clinical findings without a soluble mediator or immune mechanistic component, fall outside the scope of this collection. All manuscripts will undergo Frontiers’ standard rigorous peer review process. The topic editors declare no conflict of interest Topic editors: Cristina Wide Pissetti, Nathalie CHABBERT-BUFFET, Virmondes Jr Rodrigues Source: https://www.frontiersin.org/research-topics/86452/immunogenetics-of-inflammatory-cytokine-pathways-in-pcos-genetic-variants-and-adverse-pregnancy-outcomes