Immunomics in Aquaculture, Volume II: From Big Data to Functional Validation and Disease Resilience

The first volume of our Research Topic highlighted the transformative power of omics technologies in mapping the complex immune landscapes of fish, molluscs, and crustaceans. As the aquaculture industry continues to face evolving pathological threats and the pressures of global climate change, the need to transition from descriptive "omics" to functional and integrative "immunomics" has never been more urgent.While Volume I successfully established the "who" and the "what" of immune responses, Volume II seeks to explore the "how" and "why." We aim to move beyond single-layer data to understand the systemic interplay between the genome, epigenome, and microbiome in shaping host resilience. This volume will emphasize the integration of multiple omics layers (Multi-omics) and the use of cutting-edge tools to validate the biological significance of identified markers.A critical challenge remains the translation of high-throughput data into practical solutions for the farm. As we move forward, understanding how the environment, such as temperature fluctuations, hypoxia, and acidification, modulates the aquatic immune system via epigenetic and metabolic pathways is essential for sustainable production.The goal of this second volume is to compile a cutting-edge collection of research that utilizes advanced omics to solve practical challenges in aquaculture health management. We are particularly interested in studies that integrate multiple data types or use omics to evaluate the efficacy of novel vaccines, immunostimulants, and breeding programs for disease resistance.We invite submissions of original research, reviews, and short communications that utilize omics technologies (genomics, transcriptomics, proteomics, metabolomics, and metagenomics) to address:• Integrated Multi-Omics: Studies combining two or more omics layers to provide a holistic view of host-pathogen interactions.• Functional Immunomics: The use of CRISPR/Cas9, RNAi, or other gene-editing tools to validate immune genes identified through omics screening.• The Gut-Immune Axis: Exploring the relationship between the mucosal microbiome and systemic immunity in response to diet or pathogens.• Environmental Immunomics: How climate change stressors (heat, salinity, pollution) reshape the immune repertoire at a molecular level.• Epigenetic Regulation: Investigations into DNA methylation, histone modification, and non-coding RNAs in transgenerational immune priming and disease memory.• Precision Aquaculture: Application of metabolomic and proteomic biomarkers for early disease detection and non-invasive health monitoring.• Vaccinology and Therapeutics: Using omics to evaluate the systemic impact of novel vaccines, prebiotics, and probiotics on the aquatic immune system.Through this volume, we aim to bridge the gap between bioinformatics and bedside (or tank-side) application, fostering a more resilient and sustainable future for global aquaculture.If you are interested in submitting or have any questions, please contact the journal email: aquaculture@frontiersin.org Topic editors: Patricia Pereiro, Felipe Ascencio Source: https://www.frontiersin.org/research-topics/80195/immunomics-in-aquaculture-volume-ii-from-big-data-to-functional-validation-and-disease-resilience