Immunomodulation of Dendritic Cells and Macrophages in Bacterial Diseases

Diseases from bacterial pathogens have been a major concern worldwide and are the major cause of mortality and morbidity. Dendritic cells and macrophages are sentinel cells of host immunity during these infections and act as the interface pathogen recognition and the induction of adaptive immune responses. Afar their orthodox roles in phagocytosis and antigen presentation, these cells illustrate astonishing functional plasticity, enabling them to adopt distinct immunological states depending on microbial signals and tissue environments. Various bacterial pathogens manipulate this agility by actively reprogramming dendritic cell and macrophage functions to avoid immune clearance, bolsters intracellular survival, or prompt excessive inflammation. Current advances in immunology, immunometabolism, and system-level profiling have shown up the intricacy of these regulatory processes and emphasized their significance to disease severity, persistence, and therapeutic response.Regardless of comprehensive investigation of bacterial virulence mechanisms, a considerable void stays in understanding how immunomodulation of dendritic cells and macrophages influences protective versus pathological immune outcomes. Ongoing antibacterial approaches predominantly point out pathogen extermination, often abandoning host immune dysregulation that contributes to chronic infection or immunopathology. This topic seeks to address this challenge by incorporating mechanistic and translational studies that explore how bacterial infections modify dendritic cell and macrophage activation, signaling, and functional programming. By recognizing pathways that regulate immune balance, this topic seeks to update host-directed therapeutic strategies and enhance vaccine design against bacterial diseases.This Research Topic will encompass, but is not limited to, the following themes:• Molecular and cellular mechanisms governing dendritic cell and macrophage activation, differentiation and polarization during bacterial infections• Bacterial components and host pathways affecting antigen presentation and innate immune signaling• Roles of pattern recognition receptors during bacterial infections over the dendritic cells and macrophages• Crosstalk between dendritic cells, macrophages, and other immune cells in promoting/limiting disease outcomes• Immunomodulatory interventions targeting innate immune cells to enhance host defense or limit inflammation• Immunomodulated dendritic cell and macrophage for vaccine development, adjuvant selection, and trained immunity• Tissue-, age-, and disease-stage–specific regulation of innate immune responses Topic editors: Sanpreet Singh, Nargis Khan Source: https://www.frontiersin.org/research-topics/77938/immunomodulation-of-dendritic-cells-and-macrophages-in-bacterial-diseases