Inflammaging in Non-Communicable Diseases: Mechanisms, Biomarkers, and Translational Perspectives

The rising burden of non-communicable diseases is closely linked to the management of aging, with conditions such as cardiovascular, metabolic, neurodegeneration, cancer, and chronic respiratory illnesses increasingly prevalent in older populations. This underscores the need to better understand mechanisms driving disease susceptibility, progression and clinical heterogeneity. Persistent sterile inflammation, a chronic low-grade inflammatory state, termed inflammaging, is widely recognized as a key factor connecting physiological and molecular mechanisms of aging to the onset and progression of multiple chronic conditions. Recent technological advances have significantly expanded this complex field. High-throughput omics and multi-omics approaches, combined with computational modelling and systems biology, enable integrated analyses of age-related-inflammation, molecular and cellular changes. These approaches highlight interconnected processes such as immune dysregulation, cellular senescence, mitochondrial dysfunction, metabolic shifts, epigenetic alterations, and impaired tissue repair. They also support the discovery of inflammatory biomarkers, immune and molecular pathways to improve risk prediction, patient stratification, and personalized therapeutic strategies.This collection aims to advance a comprehensive and integrative understanding of inflammaging as a central driver of non-communicable diseases. We seek to bring together researchers spanning basic molecular biology, multi-omics analytics, and clinical immunology to foster cross-disciplinary dialogue at the intersection of aging, chronic inflammation, and disease pathogenesis. By uniting these perspectives, the collection will elucidate the cellular and molecular mechanisms underpinning inflammaging, including immune dysregulation, metabolic alterations, and tissue-specific responses. We particularly welcome contributions that bridge mechanistic insights with translational relevance. Studies integrating genomics, transcriptomics, proteomics, metabolomics, and computational modelling* are encouraged to identify robust biomarkers and predictive signatures of disease onset, progression, and therapeutic response. Emphasis will be placed on clinically relevant models and patient-derived data that enhance applicability to real-world settings. Ultimately, this collection aims to define actionable pathways linking inflammaging to the development and progression of non-communicable diseases across diverse biological systems and clinical contexts. By aligning mechanistic discovery with biomarker development and clinical validation, we seek to inform improved diagnostic strategies, personalized interventions, and novel therapeutic targets, contributing to healthier aging and reduced burden of non-communicable diseases.This Research Topic seeks to define and expand the scope of inflammaging research across basic, translational, and clinical domains. We invite original research articles, omics-driven studies, comprehensive reviews, and related contributions, including meta-analyses, that investigate inflammation-associated processes in aging and their roles in the initiation, progression, or prevention of non-communicable diseases. Contributions may address, but are not limited to:- The characterization of inflammatory and immune signalling networks- Identification and validation of immune biomarkers- Molecular and cellular determinants of disease heterogeneity- Cross-disease comparative analyses of immunological disorders. We also encourage studies focusing on patient stratification, integration of multi-omics data with appropriate validation, and computational approaches that enhance mechanistic and clinical insights. Submissions exploring novel therapeutic strategies, intervention targets, and precision medicine approaches are particularly welcome. By bringing together diverse disciplines, this collection aims to promote a more integrated and clinically relevant understanding of inflammaging and its impact on the development and management of chronic, age-associated diseases.*Please note: Studies should have an immunological focus. Studies solely focused on bioinformatic analysis without proper experimental (in vitro, in vivo or patient cohorts) validation, are out of the scope of the journal. Topic editors: Inês Mollet, Milica Bozic Source: https://www.frontiersin.org/research-topics/79862/inflammaging-in-non-communicable-diseases-mechanisms-biomarkers-and-translational-perspectives