Innovations in Antibacterial Drug Discovery and Development

The future of the global success story of the discovery of small molecule antibiotics, their evolution into viable drug therapies, and their application in the clinic over the last century, is beginning to look fragile and uncertain. The very success of antibacterial drug therapies has led to complacency, with under-investment in research and development over several decades, leading to a consequent dearth of new drug candidates with novel structure and modes of action. Meanwhile, the rise of antimicrobial resistance has resulted in the decline of efficacy of existing systems and approaches. The need for innovation in this area is becoming urgent, and this research topic seeks to highlight new approaches with promise.Drug discovery efforts to identify new effective and efficient clinically useful therapies require urgent multidisciplinary interaction to identify new opportunities crossing chemical, biochemical, pharmacological and biological boundaries, to solve not only the scientific and technical challenges of antibacterial action, but to do so in a climate of limited financial resource, tight timelines, along with constrained intellectual property and market opportunities. The goal of this issue is to highlight innovation and opportunities across all of these arenas.This research topic issue seeks submissions reporting new innovations in antibacterial drug discovery and development, especially describing novel chemical matter, novel modes of action, novel methods of delivery especially relating to materials and polymer science, and novel pharmacological function, which offer the promise of therapies which are complementary to existing clinical approaches, and which especially will counter the ever-rising threat of antimicrobial resistance. Topic editors: Mark Moloney, Hyun Ho Park, Shengwei Sun Source: https://www.frontiersin.org/research-topics/79831/innovations-in-antibacterial-drug-discovery-and-development