Innovative Formulations with Plant Extracts and Bioactive Phytoconstituents – Development, Characterization, and Potential Benefits in Health and Disease

Innovative formulations with plant extracts and bioactive phytoconstituents represent a dynamic, rapidly growing field at the intersection of natural product science, pharmaceutical technology, and integrative medicine. This field is relevant across multiple dimensions. The development of novel delivery systems – such as nanoparticles, liposomes, microencapsulation, and nanoemulsions – has significantly improved the bioavailability, stability, and targeted action of plant-derived compounds. These advances address one of the longstanding limitations of traditional herbal medicine: inconsistent or poor absorption of active constituents. Plants offer enormous chemical diversity – polyphenols, flavonoids, alkaloids, terpenes, saponins, and more – many of which have proven biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, and immunomodulatory effects.Isolating, characterizing, and formulating these compounds unlocks their therapeutic potential in a reproducible, standardized way. Beyond treating established disease, phytoconstituent-based formulations are increasingly recognized for their roles in chronic disease prevention, metabolic health, modulation of the gut microbiome, and healthy aging, aligning with the growing global interest in preventive and personalized medicine. Rigorous characterization through spectroscopic, chromatographic, and biological assays ensures safety, efficacy, and reproducibility, bridging the gap between traditional ethnobotanical knowledge and evidence-based medicine. The subject links botany, biochemistry, pharmacognosy, nanotechnology, nutrition, and clinical medicine, making it highly relevant to researchers, healthcare professionals, and the nutraceutical and pharmaceutical industries worldwide, especially as consumer demand for natural, sustainable health solutions continues to grow.This Research Topic welcomes submissions related to the development, evaluation, and application of innovative formulations containing plant extracts and bioactive phytoconstituents. Topics of interest include, but are not limited to:• Extraction, purification, and compound characterization of plant-derived constituents• Design and optimization of novel delivery systems (nanoparticles, liposomes, micro/nanoemulsions, encapsulation)• Analytical and biological evaluation of formulated natural products• Stability, safety, and bioavailability studies of phytoconstituent-based formulations• Mechanistic insights into bioactivity and therapeutic potential in disease prevention and management Topic editors: Emma Ozon, Adina Magdalena Musuc, Violeta Popovici Source: https://www.frontiersin.org/research-topics/81981/innovative-formulations-with-plant-extracts-and-bioactive-phytoconstituents---development-characterization-and-potential-benefits-in-health-and-disease