Innovative Insights into the Antibacterial Potential of Traditional Medicinal Plants through Real-Time Activity Assessment and Phytochemical Profiling

Plant-derived preparations are widely used in traditional medicine for the management of infections and wound-related conditions. These applications involve chemically complex extracts containing multiple constituents that may influence microbial growth, oxidative processes, and cellular responses associated with tissue repair. Understanding how extract composition and interactions between constituents contribute to these effects is essential for achieving reproducible and pharmacologically interpretable outcomes. A key challenge is understanding multi-component interactions within plant extracts, particularly synergistic or antagonistic effects that may influence biological activity. The efficacy of plant-derived preparations frequently depends on the combined action of multiple constituents rather than single compounds. Addressing this requires integrated approaches combining phytochemical analysis with robust biological assays, enabling more reproducible and mechanistically interpretable findings.This Research Topic aims to advance understanding of how chemically characterized plant extracts exert antibacterial and wound-healing effects, with a focus on synergistic interactions and multi-component pharmacology. The collection prioritizes studies that link chemical composition with biological activity, moving beyond preliminary screening toward reproducible, mechanism-informed insights.We welcome original research articles and reviews addressing the antibacterial and wound-healing properties of plant-derived extracts, particularly within an ethnopharmacological context.Topics include, but are not limited to:• Phytochemical profiling using HPLC, LC-MS, GC-MS, or HPTLC• Reproducible assessment of antibacterial activity• Investigation of synergistic or antagonistic interactions between extract components• Mechanistic studies on bacterial inhibition (e.g., membrane effects, biofilm modulation)• In vitro wound-healing assays (e.g., cell migration, proliferation, oxidative stress)• Correlation of chemical composition with biological activityEthical and Methodological Standards: All submissions must adhere to established best-practice guidelines in ethnopharmacology, including accurate plant identification (with voucher specimens), transparent reporting of extraction procedures, and appropriate acknowledgement of traditional knowledge sources. Manuscripts must comply with the ConPhyMP guidelines: https://ga-online.org/best-practice/ and the Four Pillars of Best Practice in Ethnopharmacology. Authors are also expected to consider ethical responsibilities related to biodiversity, cultural heritage, and the responsible use of traditional knowledge. Topic editors: Silvia Bittner Fialova, Pavel Mučaji, Claudio Ferrante Source: https://www.frontiersin.org/research-topics/79837/innovative-insights-into-the-antibacterial-potential-of-traditional-medicinal-plants-through-real-time-activity-assessment-and-phytochemical-profiling