Insights in Genomic Analysis

Sequencing technologies generate genomic data at a scale that was unimaginable a decade ago, and making sense of it depends on the methods we develop. The Genomic Analysis section sits where sequence analysis, statistics, algorithms and biology meet, turning reads into assemblies, variants and biological meaning, across organisms that range from single human genomes to microbial pan-genomes. This collection celebrates that progress: it brings together leading voices to highlight state-of-the-art developments and to set the agenda for the questions that will define the field next.This Research Topic aims to provide an overview of the most recent advances in genomic analysis. It seeks to show how accurate assembly, variant calling, annotation, comparative analysis and association methods can connect genotype to phenotype and inform research and practice, whether the subject is a patient cohort or a bacterial population. These approaches increasingly shed light on complex human conditions, from neurodegenerative diseases and aging to metabolic disorders such as diabetes. Without losing sight of past achievements, the goal is to explore the potential of future work, addressing the accuracy, scalability and data challenges that remain at the forefront of this multidisciplinary area.The scope is broadly defined yet focused on areas where significant innovative strides have been made. We welcome contributions that emphasize:• Genome assembly, long-read and pangenome methods• Variant calling, annotation and interpretation• Genome-wide association and functional genomics• Epigenomics and regulatory genome analysis• Comparative and pan-genomics of microorganisms• Pathogen genomics and applications, including reverse vaccinology• Metagenomics and microbial community genomics• Scalable algorithms and cloud workflows for genomics• Open, reproducible and FAIR genomic analysis pipelinesThis collection welcomes contributions reflecting on current developments and plotting pathways for upcoming research, from Editorial Board Members of the section, from authors they refer, and, on invitation, from a small number of external researchers whose work is shaping the direction of the field. Authors are encouraged to engage critically with their fields, identify the current challenges and propose novel solutions that advance bioinformatics tools and their application to real biological problems. Topic editors: Isabel Duarte, Vasco Ariston De Carvalho Azevedo, Siomar De Castro Soares, Lucas Santana Dos Santos Source: https://www.frontiersin.org/research-topics/83742/insights-in-genomic-analysis