Insights in Integrative Genetics and Genomics

Modern genetics has moved beyond individual loci to look at how entire genomes function as dynamic, integrated systems. The Integrative Genetics and Genomics section sits at the meeting point of population genetics, functional genomics, evolutionary biology, and systems medicine, with a particular focus on how genomic variations influence complex phenotypic traits and disease states. This collection celebrates that progress: it brings together leading voices to highlight state-of-the-art developments and to set the agenda for the questions that will define the field next.This Research Topic aims to provide an overview of the most recent advances in integrative genetics and genomics. It seeks to show how connecting sequence-level changes to molecular networks and organismal phenotypes can solve complex biological problems and inform real-world challenges in personalized medicine, agriculture, and evolutionary biology. Without losing sight of past achievements, the goal is to explore the potential of future work, addressing the technological, analytical, and data-sharing challenges that remain at the forefront of this multidisciplinary area.The scope is broadly defined yet focused on areas where significant innovative strides have been made. We welcome contributions that emphasize:• Genome-wide association studies linked to functional molecular networks• Epigenomics and transcriptomics integration across diverse tissues• Systems-level analysis of rare and common genetic variants• Comparative genomics and evolutionary systems genetics• High-throughput functional genomic screens and validation assays• Single-cell genomics and spatial transcriptomics in complex tissues• Computational methods for predicting phenotype from genotype.This collection welcomes contributions reflecting on current developments and plotting pathways for upcoming research, from Editorial Board Members of the section, from authors they refer, and, on invitation, from a small number of external researchers whose work is shaping the direction of the field. Authors are encouraged to engage critically with their fields, identify the current challenges, and propose novel solutions that advance our understanding of complex biological systems. Topic editors: Xuekui Zhang, Marco Fernandes Source: https://www.frontiersin.org/research-topics/84088/insights-in-integrative-genetics-and-genomics