Integrating Nutrition and Lifestyle: Multidomain Strategies to Enhance Quality of Life and Well-Being

Population aging, the rising burden of chronic disease, and increasing mental health concerns have made quality of life and overall well-being major public health priorities. Emerging evidence shows that health outcomes are shaped, not by isolated factors, but by the interaction of multiple lifestyle domains, including diet quality, physical activity, sleep, stress management, social engagement, and other daily behaviors. Nutrition plays a central role within this framework, influencing metabolic health, cognitive function, emotional well-being, and functional capacity across the lifespan. At the same time, multidomain lifestyle approaches appear more effective than single-focus interventions for preventing decline and promoting resilience in diverse populations. This Research Topic addresses the growing need for integrative, evidence-based strategies that examine how nutrition and complementary lifestyle factors can work together to enhance well-being, preserve function, and support healthier, more meaningful lives in clinical and community settings. This Research Topic aims to tackle a key gap in health research and practice: quality of life and well-being are still too often studied through isolated behaviors, despite growing evidence that they are shaped by the interaction of multiple lifestyle domains. Nutrition, physical activity, sleep, stress management, social connectedness, and other daily behaviors do not act independently; rather, they influence metabolic health, physical function, cognition, emotional well-being, and resilience in interconnected ways. This fragmentation may limit the effectiveness, sustainability, and real-world applicability of single-domain interventions.To address this gap, greater emphasis is needed on multidomain strategies that integrate nutrition with complementary lifestyle approaches across the lifespan. Recent advances in systems thinking, personalized and precision health, digital health tools, and community-based intervention models have created new opportunities to design, deliver, and evaluate more comprehensive and scalable solutions. This Research Topic seeks to bring together high-quality evidence on mechanisms, intervention design, implementation, and translation into practice in order to identify practical, sustainable, and evidence-based strategies that support healthier lives across diverse populations.We invite authors to submit contributions that advance understanding of how nutrition, together with other lifestyle factors, can improve quality of life and well-being across the lifespan. Submissions may include narrative, systematic reviews, mini-reviews, original research articles, and clinical or community-based studies on topics including, but not limited to:• Multidomain interventions integrating nutrition, physical activity, sleep, stress management, and social connectedness • Dietary patterns and their interaction with lifestyle behaviors in relation to physical, cognitive, and emotional well-being • Mechanisms linking nutrition and lifestyle factors to resilience, function, and chronic disease outcomes • Precision health, digital health, and technology-supported lifestyle interventions • Community-based, clinical, and population-level strategies to promote sustainable behavior change • Implementation, scalability, and real-world effectiveness of integrated lifestyle approaches This Research Topic aims to promote interdisciplinary collaboration and generate practical, evidence-based insights to improve well-being and support healthier lives across diverse populations and settings. Topic editors: Evelyn Frias-Toral, Sebastián Pablo Chapela, Rosario Suárez, Federica Fasci' Spurio Source: https://www.frontiersin.org/research-topics/80621/integrating-nutrition-and-lifestyle-multidomain-strategies-to-enhance-quality-of-life-and-well-being