Interactions Between Oral Bacteria and Gut Microbiota in Regulating Host Inflammation

The field of host-microbiome interactions has increasingly recognized the complex relationship between oral bacteria and gut microbiota, particularly regarding their effects on systemic inflammation. While the human digestive tract hosts diverse microbial communities in both the oral cavity and the gut, evidence is mounting that these two ecosystems are not isolated. Recent findings indicate that oral bacteria, especially pathogens such as Porphyromonas gingivalis, can translocate to the gut and alter its microbial balance, potentially exacerbating intestinal and systemic inflammation. However, the precise mechanisms governing how oral microbial communities influence distant sites in the body, as well as their contributions to the development of chronic inflammatory diseases, remain incompletely understood.Building on these developments, studies have begun to unravel the underlying molecular and immunological pathways that facilitate cross-talk between oral bacteria and gut microbiota. Key discoveries highlight roles for the Th17 cell-mediated immune response, microbial dysbiosis, and altered metabolite production. Advanced methods, including high-throughput sequencing, metabolomics, and the use of in vivo models, have propelled new insights into the cascade of host-microbe and microbe-microbe interactions. Despite these advances, crucial questions remain—particularly concerning the specific routes by which oral bacteria modify gut immune landscapes, and the potential for targeted interventions to mitigate inflammation-driven diseases linked to these processes.This Research Topic aims to deepen understanding of the bidirectional relationship between oral bacteria and gut microbiota, emphasizing their impact on systemic immune function and inflammation. By focusing on molecular, cellular, and ecological perspectives, the objective is to clarify the pathways by which oral microbes influence gut microbiota composition, immune modulation, and the onset of diseases such as inflammatory bowel disease and metabolic syndromes. It also seeks to highlight innovative therapeutic approaches that may emerge from disentangling these connections.To gather further insights in this rapidly evolving area, we welcome original research articles, reviews, mini-reviews, methods, perspectives and all type of articles accepted by the journal that address both mechanistic exploration and translational potential. We encourage contributions addressing, but not limited to, the following themes:o Oral microbial translocation and its consequences for gut ecosystemso Dysbiosis and immune system modulation in oral-gut axis interactionso Role of Th17 signaling and other immune pathways in oral-gut communicationo Molecular mechanisms linking oral bacteria to systemic inflammationo Therapeutic interventions targeting oral-gut microbiota cross-talko Utilization of advanced sequencing, metabolomics, and in vivo modelso Implications for chronic inflammatory and metabolic diseases Topic editors: Xiaoyuan Wei, Tsungcheng Tsai, JIANMIN CHAI, George Grant Source: https://www.frontiersin.org/research-topics/77899/interactions-between-oral-bacteria-and-gut-microbiota-in-regulating-host-inflammation