Intestinal Bacterial Biofilms under Dietary Stress: Microbial Mechanisms Driving Dysbiosis and Host Inflammation

The intestinal microbiome plays a fundamental role in maintaining host health by regulating nutrient metabolism, immune responses, and barrier function. However, dietary factors profoundly influence the composition, structure, and function of intestinal microbial communities. A growing body of evidence indicates that bacterial biofilms—a structured microbial consortium attached to the mucosal surface—serve as focal points for microbial communication and resilience under stress conditions. Under nutrient imbalance or Western-style dietary patterns, biofilm-associated bacteria can shift toward pathogenic phenotypes, leading to chronic inflammation and tissue damage. Despite advances in microbiome research, the cellular and molecular mechanisms connecting dietary stress to biofilm dynamics and microbial dysbiosis remain insufficiently understood. Recent multi-omics and imaging studies have revealed that specific dietary components, such as fats, fibers, and polyphenols, reshape microbial communities and biofilm architecture, yet the precise signaling pathways mediating these adaptations and their role in disease progression merit further exploration.This Research Topic aims to elucidate the microbial and host cellular mechanisms that link dietary stress to intestinal bacterial biofilm formation, dysbiosis, and inflammation. It seeks to integrate insights from microbial physiology, cell signaling, and host-microbe interactions to define how nutrient availability and stress cues shape collective microbial behavior and host responses. Particular attention will be given to identifying molecular determinants of biofilm resilience under varying dietary conditions and delineating how these processes contribute to intestinal pathologies including inflammatory bowel disease (IBD), metabolic syndrome, and infections. This will enhance our understanding of microbial ecology in the gut and support therapeutic strategies targeting biofilm-associated dysbiosis.To gather further insights into the cellular and infection microbiology of diet-influenced biofilms, we welcome articles addressing, but not limited to, the following themes:Molecular and cellular mechanisms regulating microbial biofilm formation under dietary stressHost-pathogen interactions shaped by nutrient composition and metabolic availabilityOmics-based approaches to characterize biofilm architecture and functional statesMicrobial communication, quorum sensing, and stress response pathways within intestinal biofilmsDiet-induced modulation of microbial metabolism and its link to tissue inflammationMechanisms of biofilm resilience and antibiotic resistance under changing nutritional conditionsTherapeutic interventions and dietary strategies targeting biofilm-mediated dysbiosis Topic editors: Honghua Hu, Marco Antonio Hernández-Luna, Paula Mendive Dubourdieu Source: https://www.frontiersin.org/research-topics/82375/intestinal-bacterial-biofilms-under-dietary-stress-microbial-mechanisms-driving-dysbiosis-and-host-inflammation