Kinase Signaling in Metabolic Health and Disease

Kinases are key regulators of metabolic processes, orchestrating cellular responses to nutrients, hormones, and environmental cues. Kinase signaling pathways play crucial roles in glucose and energy metabolism, insulin signalling, and mitochondrial function, making them essential for maintaining metabolic homeostasis. Dysregulation of kinase activity has been implicated in metabolic disorders, including obesity, type 2 diabetes, fatty liver disease, and cardiovascular complications. Although significant advances have been made in kinase research related to cancer and immunology, the pivotal roles of kinase signaling in metabolic health continue to emerge, underscoring its potential as a target for therapeutic intervention.This collection aims to explore how kinase signaling influences metabolic stability and the development and progression of metabolic diseases. Our focus is on unravelling the specific roles of kinase signaling pathways in energy balance, glucose regulation, islet function, and lipid homeostasis. We are also interested in elucidating the molecular mechanisms through which kinase dysregulation contributes to metabolic disorders and assessing the feasibility of modulating kinase signalling for therapeutic benefit. By bringing together novel research and reviews, this collection aims to connect fundamental biological insights with potential clinical applications, advancing our understanding of kinase-targeted therapies for metabolic disorders.To ensure a comprehensive exploration of this area, we welcome submissions covering, but not limited to, the following themes:• Kinase-mediated regulation of glucose, lipid, and energy metabolism• Regulation of islet biology and nutrient and hormone signaling through kinase pathways• The role of kinase signaling in obesity, diabetes, and related metabolic disorders• Development of kinase-targeted therapies for managing metabolic diseases• Interactions between kinase signaling and metabolic inflammation• Emerging kinase targets and drug-discovery approaches in metabolic healthTogether, these topics will contribute to advancing our understanding of the roles of kinase signalling in metabolic health and disease, as well as its potential for therapeutic application. Topic editors: Kim Loh, Kamal D Mehta Source: https://www.frontiersin.org/research-topics/85801/kinase-signaling-in-metabolic-health-and-disease