Long non-coding RNAs: their role in diverse cellular pathways, metabolism and genomic stability

Long noncoding RNA (lncRNA) are ~200 nucleotide long RNAs molecules synthesizedby the cell from different regions across the genome, such as the intergenic andintragenic(intronic) regions that do not encode protein. Nevertheless, they contribute toa myriad of cellular activities, such as transcriptional regulation, animal development,genetic integrity maintenance and tumor suppression. Importantly, abnormal levels ofexpression of many lncRNAs and mutational alteration of their binding lead todisruption of gene regulation and these are often linked to inflammatory diseases thatfall under neurologic, cardiovascular, and autoimmune disorders, rare geneticdiseases, and cancer. This makes them a significant topic to better understand cellularprocesses. However, a great deal of information remains to be gathered on lncRNAs.Further work will bring novel insights to the mode of action of lncRNAs that couldbenefit both the basic and translational science identifying novel therapeutic optionsand discovering potential drug-targets.This special issue invites works on different aspects of the lncRNA biology, includingtheir synthesis, localization, spatiotemporal dynamics and functionalities. Major focuswill be on studies revealing the structure-function relationship and biochemical aspectsof lncRNA interactions with binding partners and the consequences of this binding onkey cellular mechanisms, such as the DNA-repair pathways, cellular differentiation andproliferation. However, interdisciplinary approaches utilizing single cell techniques,multi-omics approach and computational biology are also encouraged. Potential yet non-exclusive areas of interest are as follows:● Interplay between lncRNA and key interactors like proteins, DNA and ensuingchromatin modifications, its impact on transcription, cell viability and growth● Studies on the relationship behind the lncRNAs regulation, dynamics and diseases● Development of new tools to broadly advance lncRNA studies.● Identification of novel putative drug-targets.Authors are welcome to submit articles presenting original studies or literature review work. Please consult the journal's information regarding Article Types, Author Guidelines, and Publishing Fees, or direct any questions to the Editorial Office: abp@frontierspartnerships.org.Even though abstract submission is not mandatory, we encourage all interested researchers to submit a “manuscript summary” before submitting their article. Manuscript summaries do not have to coincide with the final abstract of the article. Topic editors: Soham Seal, Sushmit Ghosh, Apurba Sarkar Source: https://www.frontierspartnerships.org/research-topics/241/long-non-coding-rnas-their-role-in-diverse-cellular-pathways-metabolism-and-genomic-stability