Mechanism of neuroinflammation and oxidative stress in stroke and brain injuries

Neuroinflammation and oxidative stress are increasingly recognized as central mechanisms underlying the pathophysiology of stroke and traumatic brain injury. Following ischemic, hemorrhagic, or traumatic insults, a cascade of inflammatory and redox responses, including microglial activation, astrocyte reactivity, peripheral immune-cell infiltration, mitochondrial dysfunction, blood–brain barrier disruption, and excessive production of reactive oxygen species, contributes to neuronal dysfunction, secondary tissue damage, and progressive neurodegeneration. Although substantial progress has been made in characterizing these molecular and cellular processes, effective therapeutic strategies targeting neuroinflammation and oxidative stress remain limited.This Research Topic aims to provide a platform for emerging discoveries and translational research in this rapidly developing field. We welcome Original Research, Reviews, Mini-Reviews, Perspectives, and other suitable article types investigating molecular signaling pathways, immune responses, glial-cell interactions, mitochondrial and metabolic dysfunction, blood–brain barrier impairment, redox imbalance, regulated cell death, and the mechanisms shaping acute, subacute, and chronic neurological injury.The Research Topic also welcomes studies on novel biomarkers, neuroprotective strategies, pharmacological interventions, drug discovery, drug repurposing, gene- and cell-based therapies, extracellular vesicles, nanomedicine, and advanced experimental models relevant to stroke and traumatic brain injury. Particular emphasis will be placed on studies that identify and validate therapeutic targets, clarify treatment mechanisms and therapeutic windows, and bridge basic neuroscience with clinical applications in diagnosis, prognosis, and therapeutic development.Studies addressing Alzheimer’s disease and Parkinson’s disease are also welcome, particularly those exploring shared mechanisms and therapeutic opportunities related to neuroinflammation, oxidative stress, mitochondrial dysfunction, protein homeostasis, regulated cell death, and neurodegeneration. Studies investigating the relevance of these mechanisms to stroke, traumatic brain injury, post-injury neurodegeneration, or broader neuronal injury are especially encouraged.By bringing together researchers and clinicians from neuroscience, immunology, redox biology, pharmacology, and translational medicine, this Research Topic seeks to advance understanding of neuroinflammatory and oxidative mechanisms in stroke and brain injury and to promote innovative therapeutic approaches that can reduce secondary damage, support neurological recovery, and limit long-term neurodegenerative consequences. Topic editors: William James Antonisamy, Zhiyou Yang, RAVI CHIDAMBARAM Source: https://www.frontiersin.org/research-topics/81613/mechanism-of-neuroinflammation-and-oxidative-stress-in-stroke-and-brain-injuries