Mechanisms and Management of Fungicide Metabolism and Resistance

The impact of fungicides in fungal resistance to a variety of agricultural and clinical drug therapies is one of the most pressing problems to be solved by fungal biologists. Resistance not only threatens crop productivity and human health but also reshapes fungal communities across natural and anthropogenic environments. While genetic and molecular mechanisms of resistance are increasingly described, the metabolic consequences of fungicide exposure and adaptation remain underexplored. Metabolic rewiring, altered nutrient utilization, and stress tolerance responses can profoundly influence fungal physiology, virulence, and persistence. Understanding these interconnected processes across environmental, agricultural, and clinical contexts is key to mitigating the global rise of antifungal resistance.This Research Topic aims to bring together multidisciplinary studies that dissect the mechanisms and broader consequences of fungicide resistance in fungi. We invite contributions that explore how resistance emerges, stabilizes, and propagates within populations and microbial communities. Particular emphasis will be placed on how fungicide pressure triggers metabolic adaptations that affect fungal growth, virulence, and ecological fitness. We also welcome integrative studies that link molecular and biochemical mechanisms with environmental or clinical observations, including the spread of resistant strains in soil, plant, and host-associated niches. By bridging mechanistic and ecological perspectives, this Research Topic seeks to provide a comprehensive view of how fungicides shape fungal evolution, physiology, and pathogenic potential, ultimately informing more sustainable antifungal strategies.We welcome a wide range of article types, including original research, reviews, mini-reviews, methods, and perspectives. Topics of interest include (but are not limited to):- Molecular, genetic, and biochemical mechanisms of fungicide resistance- Metabolic and physiological adaptations associated with resistance- Environmental and clinical dissemination of resistant fungi- Mycobiome-level responses to antifungal or pollutant stress- Evolutionary and ecological consequences of fungicide exposureInterdisciplinary and comparative studies that connect agricultural, clinical, and environmental systems are particularly encouraged. Contributions combining genomics, metabolomics, transcriptomics, or experimental ecology approaches are highly welcome. Topic editors: Celso Martins, Tiago M Martins, Gustavo Henrique Goldman Source: https://www.frontiersin.org/research-topics/75566/mechanisms-and-management-of-fungicide-metabolism-and-resistance