Mechanobiology and Mechanomedicine in Tissue Remodeling and Regeneration

Mechanobiology is a rapidly evolving field within physiology that explores the fundamental role of mechanical forces in cellular and tissue function. Increasing evidence shows that biomechanical cues—such as stretch, tension, compression, and matrix stiffness—are key regulators of cellular signaling, differentiation, and homeostasis. Disruption of these mechanical environments can contribute to maladaptive tissue remodeling and impaired regeneration. Recent studies have highlighted key molecular and structural mediators, including cell adhesion complexes, extracellular matrix (ECM) organization, and cytoskeletal dynamics, which coordinate the conversion of physical forces into biological responses. Innovative technologies like organ-on-a-chip, microfluidics, advanced imaging, and computational modeling have further deepened our understanding of how mechanical forces regulate tissue behavior. However, challenges remain in fully elucidating the dynamic interplay between mechanics and biology, and in translating these insights into practical therapeutic strategies.This Research Topic aims to bridge the gap between fundamental mechanobiological discoveries and their application in mechanomedicine. Our objective is to assemble research that clarifies how mechanical signaling is orchestrated at the molecular, cellular, and tissue levels, and how these mechanisms can be manipulated for therapeutic benefit. We especially seek contributions that propose or validate new strategies—whether biomaterial-based, pharmacological, or device-driven—to modulate mechanical microenvironments and mechanical signaling for improved tissue repair and regeneration. By gathering both experimental and theoretical work, we seek to advance the understanding of mechanotransduction and accelerate its translation into targeted interventions in physiological and pathological contexts.This Research Topic will cover research from molecular mechanisms to translational and therapeutic innovation, but will not include studies unrelated to mechanical signaling or mechanotransduction. To further advance this field, we welcome articles addressing, but not limited to, the following themes:• Adhesion complexes, cytoskeletal regulation, and ECM dynamics in force sensing and mechanical signal transduction• Mechanical regulation of tissue remodeling, regeneration, and inflammation in mechanically active tissues• Engineering approaches: biomaterial scaffolds, devices, and microenvironments designed to mimic or manipulate mechanical cues• Mechanotherapies, including drugs, nanoparticles, and delivery systems that modulate mechanotransduction-related pathways or mechanical microenvironments• Advanced technologies and computational models—such as organ-on-a-chip, microfluidics, imaging, or AI modeling—enabling mechanobiological discovery or therapeutic developmentWe invite the submission of original research articles, reviews, and perspective pieces that contribute to the understanding and therapeutic exploitation of mechanobiology and mechanomedicine. Topic editors: Xianglong Han, Hui Xu, Xianrui Yang Source: https://www.frontiersin.org/research-topics/76949/mechanobiology-and-mechanomedicine-in-tissue-remodeling-and-regeneration