Microbial Dysbiosis in Systemic Diseases: Adaptive and Innate Immune Mechanisms in Infection

Microbial dysbiosis has emerged as a central factor influencing host susceptibility to infection and the development of systemic immune dysfunction. While alterations in microbial communities have been widely associated with chronic and multisystem disorders, the mechanisms by which dysbiosis shapes host responses to invading pathogens remain incompletely understood. In particular, growing evidence suggests that dysbiosis can influence innate immune sensing, inflammatory signaling, epithelial and mucosal barrier integrity, and the induction or impairment of protective adaptive immunity. These interactions are highly relevant to the scope of Adaptive & Innate Immunity in Infection, which emphasizes mechanistic insight into immune recognition, regulation, and host–microbe interactions during infection.This Research Topic aims to gather articles that explore how microbial imbalance contributes to infection-associated immune dysregulation in systemic disease settings. We welcome submissions addressing the effects of dysbiosis on pattern-recognition receptor signaling, inflammasome activation, cytokine and chemokine responses, antigen presentation, T-cell and B-cell immunity, pathogen persistence, and immune evasion strategies. Studies examining host–pathogen–microbiome crosstalk, microbial translocation, and the immune consequences of disrupted microbial ecosystems across tissues and organ systems will be particularly encouraged. By focusing on the molecular, cellular, and systemic immune mechanisms linking dysbiosis to infection-related disease processes, this Research Topic will provide a timely platform for advancing our understanding of how altered microbial communities influence both innate and adaptive immunity in health and diseaseWe welcome articles addressing, but not limited to, the following themes:-Mechanistic links between microbial dysbiosis and host susceptibility to infection-Dysbiosis-driven modulation of innate immune sensing and signaling pathways-Effects of microbial imbalance on inflammatory responses and immune regulation-Impact of dysbiosis on epithelial and mucosal barrier integrity during infection-Roles of dysbiosis in shaping protective or impaired adaptive immune responses-Pattern-recognition receptor signaling in dysbiosis-associated infection-Inflammasome activation and downstream cytokine and chemokine responses-Antigen presentation, T-cell immunity, and B-cell responses in dysbiotic settings-Host–pathogen–microbiome crosstalk, microbial translocation, and pathogen persistence-Immune evasion and systemic immune dysfunction linked to disrupted microbial ecosystems Topic editors: Huseyn Babayev, Sena Ardicli, Ozge Ardicli Source: https://www.frontiersin.org/research-topics/79497/microbial-dysbiosis-in-systemic-diseases-adaptive-and-innate-immune-mechanisms-in-infection