Microbiome-Endocrine Crosstalk in Metabolic and Reproductive Disorders Mechanisms, Biomarkers, and Translational Therapeutic Strategies

The gut microbiota is now recognized as a key regulator of the endocrine system, greatly surpassing its traditional metabolic roles. Science has shed light on Really the gut microbiota-endocrine axis is very interactive and is responsible for integrating metabolic, immune as well as neuroendocrine signaling pathways. A breakdown of this axis has been linked to several endocrine and metabolic diseases such as obesity, type 2 diabetes mellitus, polycystic ovary syndrome (PCOS), thyroid dysfunction, and metabolic syndrome. Increasingly, microbial metabolites (mainly short-chain fatty acids, secondary bile acids, and tryptophan metabolites) are being tied to the modulation of insulin sensitivity, inflammatory pathways, energy homeostasis, and steroid hormone signaling. But, hormones (like insulin, glucocorticoids, thyroid hormones, and sex steroids) are capable of altering the microbial profile, diversity, and functional attributes, so creating a highly plastic regulatory system that links metabolism and reproduction. At the same time, environmental and lifestyle factors like dietary changes, endocrine-disrupting chemicals, circadian rhythm changes, chronic psychological stress, and long-term medication use greatly influence both the endocrine system and gut microbial populations. Although investigators have made good progress, there are still many unanswered questions - causal mechanisms, inter-individual differences, longitudinal microbial changes, and clinically useful biomarkers are some examples. One of the big challenges in the translation of microbiome research is how to turn them into precision endocrinology diagnostics and therapeutics.This research project is designed to uncover the microbiome-endocrine mechanisms that contribute to metabolic and reproductive disorders using translational and clinical research. The major focus areas are microbial biomarkers, metabolite-mediated hormonal regulation, environmental factors, and microbiome-based therapies. The project will result in the development of precision diagnostic tools, forecasting models, a systems approach to understanding endocrine functions, and the creation of therapeutically relevant strategies that will help in the extension of precision endocrinology and personalized metabolic care to a wider range of populations.1. Role of intestinal microbiota in the pathogenesis of metabolic disorders such as obesity, diabetes mellitus, and metabolic syndrome.2. Interactions between the microbiome and reproductive hormones, including microbiome involvement in PCOS, infertility, and hormonal disorders.3. The "thyroid-gut microbiome axis" and its correlation with thyroid disease and other disorders.4. Microbial metabolites as mediators of endocrine pathways.5. The communication of gut-brain-endocrine networks and their integration.6. The influence of endocrine-disrupting chemicals on microbiome composition and function.7. Gender-specific, developmental, and life-course interaction of the microbiome and hormonal regulation.8. Use of the microbiome for diagnostics, prognosis, and patient stratification in endocrine disorders.9. Microbiome therapeutics via diet probiotic, synbiotic, and postbiotic interventions.10. Interactions between drug-microbiome-hormones in endocrine pharmacology.The integration of multi-omics, systems biology, and artificial intelligence (AI)-based predictive modeling in microbiome-endocrine research. Topic editors: ABHISHEK OJHA, SUCHITRA KAMLE, Dr Abhishek Gupta Source: https://www.frontiersin.org/research-topics/81840/microbiome-endocrine-crosstalk-in-metabolic-and-reproductive-disorders-mechanisms-biomarkers-and-translational-therapeutic-strategies