Microbiota, Nutrition, and Gastrointestinal Disorders: From Mechanisms to Clinical Applications

The field of nutrition and digestive health has increasingly recognized the pivotal influence of the gut microbiota on gastrointestinal physiology and disease. The human gut harbors a highly diverse microbiome that interacts with dietary factors to modulate nutrient metabolism, immune responses, and the maintenance of intestinal barrier integrity. Disruptions in this balance, commonly referred to as dysbiosis, have been proposed as central contributors to the pathogenesis of various gastrointestinal disorders, such as inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, and metabolic-related gut dysfunctions. Recent advances in omics technologies and microbial ecology have deepened our understanding of these complex interactions, yet substantial questions remain. Ongoing debates center around how specific nutrients and dietary patterns shape the microbiome, and how these changes translate into disease susceptibility or protection.Growing evidence suggests that targeted nutritional interventions can favorably modulate the gut microbiota, potentially alleviating symptoms or even altering disease trajectories in gastrointestinal disorders. Clinical and translational studies have begun to identify microbial biomarkers linked to diet responsiveness and treatment outcomes. Despite these efforts, translating mechanistic insights into effective and individualized therapies is still in its infancy, complicated by patient heterogeneity and multifactorial disease origins. The integration of basic research, clinical trials, and systems-level analyses is essential to unravel the precise mechanisms by which nutrition and microbiota interdependently affect gastrointestinal pathophysiology.This Research Topic aims to consolidate current knowledge on the relationship between diet, gut microbiota, and gastrointestinal health and disease. It strives to highlight mechanistic pathways, evaluate evidence for microbiota-targeted nutritional interventions, and explore the translation of microbiome science into clinical practice. Key questions include how specific dietary patterns impact the microbiome’s composition and function, the extent to which microbiota modifications can be leveraged for disease management, and the viability of personalized nutrition as a therapeutic approach for gastrointestinal disorders.To gather further insights in this rapidly evolving area and to bridge fundamental and clinical research, we welcome articles addressing, but not limited to, the following themes:• Mechanisms linking dietary components and microbial metabolism in the gut.• Effects of specific diets, nutrients, and probiotics/prebiotics on gastrointestinal disorders.• Gut microbiota alterations as biomarkers for disease risk, prognosis, and therapeutic response.• Clinical trials and interventions targeting gut microbiota through nutrition.• Systems biology and multi-omics approaches in gut microbiota and nutrition research.• Personalized nutrition and individualized modulation of the microbiome for gastrointestinal health. Topic editors: Nallely Bueno-Hernández, Jose Maria Remes-Troche, Viridiana M. Mendoza-Martínez, Octavio Gomez-Escudero Source: https://www.frontiersin.org/research-topics/75819/microbiota-nutrition-and-gastrointestinal-disorders-from-mechanisms-to-clinical-applications