Mitochondrial quality control and signalling networks in cellular homeostasis and disease

Mitochondria are central regulators of energy production, metabolism, and cell survival. Their function and integrity depend on tightly controlled quality control mechanisms-including mitochondrial fission, fusion, and mitophagy-that adapt mitochondrial networks to cellular demands. Disruption of these processes leads to mitochondrial dysfunction, altered signalling, and the development of numerous pathological conditions. Increasing evidence also underscores how stress responses and cytokine-mediated pathways influence mitochondrial function and contribute to disease progression.This Research Topic aims to gather original research and reviews that advance our understanding of mitochondrial maintenance and signalling regulation in health and disease. We welcome multidisciplinary contributions using molecular, imaging, biochemical, and physiological approaches to dissect how mitochondrial dynamics and stress pathways sustain cellular homeostasis. Studies linking mitochondrial quality control and signalling dysfunction to ageing, inflammation, neurodegeneration, and metabolic disorders are particularly encouraged.Areas to be covered may include, but are not limited to:• Mechanisms of mitochondrial fission, fusion, and mitophagy• Cytokine- and stress-mediated regulation of mitochondrial function• Mitochondrial signalling pathways in physiological and pathological contexts• Crosstalk between mitochondrial dynamics and cellular metabolism• Imaging and structural analysis of mitochondrial organization and turnover Topic editors: Harlokesh Narayan Yadav, Chunxin Black Wang Source: https://www.frontiersin.org/research-topics/82840/mitochondrial-quality-control-and-signalling-networks-in-cellular-homeostasis-and-disease