Mitohormesis in Health and Disease: a Friend or Foe

Mitochondria fulfil acute and chronic energetic needs required for the proper functioning of cells. A variety of insults can activate the mitochondrial retrograde response, which instigates broad nuclear and cytosolic responses to influence mitochondrial homeostasis, known as mitohormesis. The energy source ATP, as well as several bioactive intermediates of the TCA cycle, trigger numerous cytosolic molecular cascades to maintain cellular homeostasis. Toxic shifts in the activity of intermediate bioactive metabolites set off several cytosolic signalling cascades, including epigenetic modifications, ion channel modulation, inflammation, and oxidative stress. Changes in mitohormesis can also affect the trajectory of metabolic and neurological disorders. Altogether, these observations suggest that mitohormesis may play a key role in the pathogenesis and later development of various disorders, and that its regulation may provide potential therapeutic options for the prevention of these disorders.Currently, metabolic and neurological disorders have a pivotal impact on human health globally. Mitochondria are centrally associated with different metabolic processes which affect cellular functioning. This Research Topic aims to understand the intricacy of mitohormesis, which elicits numerous cellular responses associated with pathology, as well as investigate potential strategies for improving outcomes for patients suffering from neurological and metabolic complications.This Research Topic presents cutting-edge research that provides a comprehensive overview of the mechanisms involved in the pathogenesis of metabolic and neurological disorders, with an emphasis on mitochondrial processes. We welcome Original Research, Reviews, Mini Reviews, Methods and Perspective articles addressing, but not limited to:• Role of mitohormesis in the pathogenesis of neurological and metabolic disorders.• Mitochondrial quality control, mitophagy and biogenesis as drivers of the mitohormetic response.• Novel therapeutic approaches that target mitohormesis in neurological and metabolic disorders.• Identification of mitochondrial homeostasis biomarkers that are linked with health and disease.• Role of metabolic intermediates in the pathogenesis of neurological or metabolic disorders.• Lifestyle and dietary interventions, such as exercise and caloric restriction, and the molecular mechanisms through which they modulate mitohormesis in neurological and metabolic disease. Topic editors: Guanglin Zhang, Pragyanshu Khare, Pavan Thapak Source: https://www.frontiersin.org/research-topics/85786/mitohormesis-in-health-and-disease-a-friend-or-foe