Mitral and Tricuspid Regurgitation: Staging, Referral, and Heart Failure Burden

Structural heart disease and heart failure frequently coexist and amplify each other through adverse remodeling, congestion, impaired forward flow, and progressive functional limitation. While left ventricular systolic dysfunction remains a major driver, lesions such as aortic stenosis and atrioventricular valve regurgitation can precipitate or worsen heart failure across the full spectrum of ejection fraction. In clinical practice, severity and risk are often underestimated until patients present with recurrent decompensation, multi organ involvement, or irreversible ventricular and atrial remodeling.This Research Topic addresses the need for integrated, evidence based strategies that connect structural pathology to heart failure phenotype, trajectory, and outcomes. Unlike device centered collections, this Topic focuses on the clinical heart failure pathway created by structural lesions, emphasizing staging, timing of referral and intervention, and longitudinal management and outcomes, with transcatheter therapies considered within an integrated care strategy. A particular emphasis is placed on mitral and tricuspid regurgitation, where timely recognition and appropriately timed transcatheter treatment may reduce heart failure burden, hospitalizations, and downstream cardiovascular events, especially when combined with optimized guideline directed medical therapy and structured follow up.We welcome Original Research, clinical trials, observational and registry studies, translational research, systematic reviews, meta analyses, state of the art reviews, and consensus style manuscripts addressing:• Staging and risk stratification for MR and TR in heart failure, including RV function, pulmonary hypertension, and congestion phenotypes;• Referral timing and care pathways, including heart team models and implementation studies;• Definitions of response, non response, and futility using HF endpoints and patient reported outcomes;• Pre and post intervention optimization, including GDMT, rhythm management, and longitudinal surveillance strategies;• Health services research, equity and access, and health economic impact of earlier structural intervention in HF. Topic editors: Christos Iliadis, Felix Rudolph Source: https://www.frontiersin.org/research-topics/79030/mitral-and-tricuspid-regurgitation-staging-referral-and-heart-failure-burden