Model-Informed Precision Dosing of Anti-Infectives in Neonates and Children

Optimizing anti-infective therapy in neonates and children remains a significant clinical challenge due to developmental changes in pharmacokinetics and pharmacodynamics, high interindividual variability, and limited prospective data. Model-informed precision dosing (MIPD) has emerged as a powerful framework to address these challenges by integrating population pharmacokinetic modeling, physiologically based approaches, and therapeutic drug monitoring to individualize dosing strategies.This Research Topic aims to bring together advances in MIPD for anti-infective agents across neonatal and pediatric populations. We welcome contributions that explore pharmacokinetic and pharmacodynamic modeling approaches, including those accounting for developmental physiology.We also seek work that bridges methodology and clinical application. The overall goal is to advance precision dosing strategies that improve efficacy and safety outcomes in this vulnerable population.Sub-themes of interest include:- Population pharmacokinetic and pharmacodynamic modeling- Semi-mechanistic and physiologically based models- Developmental physiology in dosing: renal maturation and evolving clearance pathways- Variability in drug exposure and covariate identification- Translation into clinical decision support tools- Implementation of MIPD in real-world clinical settings- Integration with therapeutic drug monitoring programs- Exposure-response relationships in anti-infective therapy- Anti-infective drug classes: glycopeptides, aminoglycosides, beta-lactams, and newer agents Topic editors: Elena Y Enioutina, Angela Birnbaum, Josh Courter, Catherine M T Sherwin Source: https://www.frontiersin.org/research-topics/82274/model-informed-precision-dosing-of-anti-infectives-in-neonates-and-children