Modulating Epithelial-Mesenchymal Transition within the Tumor Microenvironment for Targeted Cancer Therapy

The epithelial-mesenchymal transition (EMT) is a dynamic and reversible process by which epithelial tumor cells acquire mesenchymal characteristics, increasing their migratory, invasive, and stem-like properties. EMT is now recognized as a central mechanism in cancer progression, metastasis, recurrence, and therapeutic resistance. Importantly, EMT is not an isolated event but is orchestrated and modulated by the tumor microenvironment (TME)—an intricate network of stromal cells, immune cells, extracellular matrix components, and soluble mediators.Recent advances have highlighted that targeting EMT within the TME offers a promising avenue for precision cancer therapy. Potential strategies include inhibiting canonical EMT transcription factors (such as Snail, Slug, ZEB1/2, and Twist), interfering with matrix remodeling enzymes (like matrix metalloproteinases), and modulating the signaling pathways (TGF-β, Wnt, Notch, etc.) at the tumor-stroma interface. Furthermore, emerging studies suggest that targeting the crosstalk between cancer cells and non-malignant cells in the TME (e.g., cancer-associated fibroblasts, immune infiltrates) can effectively restrain EMT-driven tumor phenotypes and restore sensitivity to conventional therapies.This research topic aims to gather innovative studies elucidating the molecular interplay between EMT and the tumor microenvironment, identify promising therapeutic targets, and explore the translational potential of EMT modulation in various cancer types. We welcome original research, reviews, and perspectives covering:• The mechanistic basis of EMT regulation by the TME;• The dual immunological and metastatic consequences of EMT modulation;• Preclinical and clinical advances in EMT-targeted interventions;• Novel biomarkers predicting EMT plasticity or therapeutic response.By advancing our understanding of EMT within the context of the TME, we can pave the way for more effective, less toxic, and personalized cancer treatments. Topic editors: Amir Barzegar Behrooz, Maria Virumbrales Munoz, Venkataswarup Tiriveedhi Source: https://www.frontiersin.org/research-topics/73457/modulating-epithelial-mesenchymal-transition-within-the-tumor-microenvironment-for-targeted-cancer-therapy