Molecular and Cellular Adaptations in High-Altitude Environments: Mechanisms to Therapeutic Innovations

High-altitude environments impose distinctive physiological and cellular stresses, including hypoxia, oxidative stress, and immune modulation. These challenges induce molecular and cellular adaptations that reshape blood function, vascular dynamics, and tissue metabolism. Understanding how organisms detect, respond to, and tolerate such extreme conditions provides key insights into both fundamental biology and human health.This Research Topic aims to gather experimental and review studies that illuminate the molecular and cellular mechanisms underlying adaptation to high altitude across species and systems. We welcome multidisciplinary contributions combining physiology, molecular biology, genomics, and bioengineering to reveal how hypoxic environments drive cellular remodelling and evolutionary innovation. Studies that link these mechanisms to clinical, diagnostic, or therapeutic advances are particularly encouraged.Areas to be covered may include, but are not limited to:• Molecular pathways and sensors mediating hypoxic adaptation• Cellular mechanisms in blood, vascular, and immune systems under chronic hypoxia• Comparative and model systems for studying high-altitude biology• Emerging technologies and methodological innovations for high-altitude research• Translational and therapeutic approaches targeting hypoxia-related disorders• Evolutionary and population-level perspectives on high-altitude adaptation Topic editors: Sheng Ding, Dianxiang Lu, Ruoli Chen Source: https://www.frontiersin.org/research-topics/84138/molecular-and-cellular-adaptations-in-high-altitude-environments-mechanisms-to-therapeutic-innovations