Molecular and Omics Insights into Male and Female Reproductive Microenvironments: From Cellular Crosstalk to Biotechnological Applications

In domestic, livestock, companion, and wild animal species, the male and female reproductive tracts are highly dynamic and tightly regulated systems in which coordinated molecular events determine gamete development and transport, fertilization, embryo development, and pregnancy establishment. Reproductive success depends on the composition and regulation of specialized microenvironments within the testis, epididymis, and accessory sex glands, as well as the ovary, oviduct, and uterus. Recent advances in proteomics, metabolomics, transcriptomics, extracellular vesicle research, and systems biology are providing unprecedented insights into these complex regulatory networks.We welcome original research articles and reviews addressing the molecular and cellular mechanisms underlying spermatogenesis, sperm maturation, capacitation, follicular development, oocyte competence, in vitro maturation, fertilization, early embryo development, uterine receptivity, embryo transfer, embryo–maternal dialogue, and gestation.Studies investigating the effects of assisted reproductive technologies, in vitro sperm capacitation, cryopreservation, ovulation induction protocols, embryo transfer strategies, environmental stressors, and management practices on reproductive microenvironments are particularly encouraged. Studies addressing the interplay between reproductive anatomy and assisted reproductive technologies, including minimally invasive techniques for improving reproductive procedures and outcomes, are also encouraged. Contributions may include integrative or comparative studies linking molecular profiles with fertility, animal health, and reproductive efficiency.Research applying multi-omics approaches, single-cell technologies, and extracellular vesicle characterization to reproductive processes is especially welcome. Interdisciplinary perspectives connecting reproductive biology with animal welfare, sustainability, conservation, and species management are also encouraged. Topic editors: Martin Eduardo Argañaraz, Juan Manuel Teijeiro, Calogero Stelletta Source: https://www.frontiersin.org/research-topics/85110/molecular-and-omics-insights-into-male-and-female-reproductive-microenvironments-from-cellular-crosstalk-to-biotechnological-applications