Molecular Mechanisms and Dynamics of Clathrin-Mediated Endocytosis

Clathrin-mediated endocytosis (CME) is a fundamental cellular process governing nutrient uptake, receptor signaling, membrane homeostasis, and synaptic vesicle recycling. Over the past decade, advances in live-cell imaging, quantitative image analysis, and biophysical reconstitution have transformed our understanding of how clathrin-coated pits assemble, mature, and are shaped into vesicles, revealing a highly regulated, multi-step process rather than a uniform default pathway.This Research Topic aims to bring together current research on the molecular machinery and regulatory mechanisms that drive CME, from initial nucleation of clathrin-coated pits to membrane scission and vesicle release. We welcome contributions that combine structural, biophysical, cell biological, and computational approaches to dissect the coordination of coat proteins, adaptors, curvature-generating factors, and mechanoenzymes during endocytosis.Areas of interest include, but are not limited to:Assembly and maturation dynamics of clathrin-coated pitsRoles of BAR-domain proteins and other curvature-sensing/-generating factors in membrane shapingDynamin and other GTPases in vesicle scissionAdaptor protein complexes and cargo selection in CMEQuantitative and computational methods for classifying endocytic stagesRegulation of CME by disease-relevant signaling pathways (e.g., receptor tyrosine kinase trafficking)Non-canonical or accessory regulators of endocytic dynamicsCrosstalk between clathrin-mediated endocytosis and other membrane trafficking pathways Topic editors: Intaek Lee, Zhiming Chen Source: https://www.frontiersin.org/research-topics/85535/molecular-mechanisms-and-dynamics-of-clathrin-mediated-endocytosis