Molecular Mechanisms and Pathophysiology of Dry Eye Disease and Meibomian Gland Dysfunction Volume II

Dry eye disease (DED) and meibomian gland dysfunction (MGD) are highly prevalent ocular surface disorders that can substantially impair quality of life. MGD, one of the most common ocular surface diseases, is a major contributor to DED, particularly the evaporative subtype. Despite their high prevalence and clinical significance, the molecular mechanisms and pathophysiological processes underlying DED and MGD remain incompletely understood, highlighting the need for further investigation.Important areas of research include the roles of inflammation, oxidative stress, and neurogenic factors, as well as the interactions among these processes. In addition, the complex interplay between systemic and local factors in the onset and progression of DED and MGD is critical to understanding their pathogenesis. Animal models and in vitro systems are indispensable tools for elucidating the cellular and molecular mechanisms of these disorders. Advances in these areas may support the development of novel therapeutic approaches and improve management strategies for patients with DED and MGD. This Research Topic aims to advance current knowledge of the molecular pathways and pathophysiological mechanisms involved in DED and MGD. By bringing together basic, translational, and clinically oriented studies, this collection seeks to clarify disease biology, identify new therapeutic targets, and promote the development of innovative treatment strategies. Through interdisciplinary collaboration, this Research Topic will provide a platform for accelerating the translation of mechanistic insights into improved management and clinical outcomes for patients affected by these ocular surface disorders. This Research Topic welcomes submissions addressing the molecular, pathophysiological, and therapeutic aspects of DED and MGD. Contributions are expected to emphasize originality, mechanistic insight, and translational relevance. We welcome articles addressing, but not limited to, the following themes:• Molecular mechanisms in DED and MGD• Inflammatory mediators, oxidative stress, and neurogenic factors in ocular surface disease• Pathophysiological interactions between systemic and local factors• Disease initiation, progression, and heterogeneity in DED and MGD• Novel pharmacological and non-pharmacological therapeutic interventions• Development and refinement of animal models of DED and MGD• In vitro models for mechanistic and therapeutic research• Emerging strategies to improve disease management and clinical outcomes Topic editors: Jillian Ziemanski, Yang Liu, Jinghua Bu, Yang Wu Source: https://www.frontiersin.org/research-topics/79136/molecular-mechanisms-and-pathophysiology-of-dry-eye-disease-and-meibomian-gland-dysfunction-volume-ii