Multiplex Genome Editing to Overcome Tumor Immune Evasion

Tumor immune evasion remains one of the greatest obstacles to achieving durable responses in cancer therapy. Tumors often employ multiple and overlapping mechanisms to escape immune recognition and destruction, such as downregulation of antigen presentation, modulation of immune checkpoints, and alteration of the tumor microenvironment. With advances in genome editing technologies—including CRISPR/Cas9, base editing, and prime editing—researchers now have powerful tools to simultaneously target and modify multiple genes, enabling a new generation of precision immunotherapies.This Research Topic aims to showcase the latest developments and applications in multiplex genome editing designed to overcome tumor immune evasion. We welcome original research articles, reviews, mini-reviews, methods papers, and perspectives across a range of tumor types and immune cell platforms. Topics of interest include, but are not limited to:1. Novel genome editing strategies to simultaneously target multiple immune evasion pathways in cancer cells2. Engineering immune cells (e.g., T cells, NK cells, macrophages) using multiplex gene editing to enhance anti-tumor activity3. Mechanisms and models of tumor immune evasion addressed through multiplex editing approaches4. Preclinical and clinical data on multiplex-edited immune cell therapies5. Delivery systems and technologies for efficient multiplex editing6. Ethical, safety, and regulatory considerations for multiplexed gene editing in cancer therapyWe invite contributions that advance mechanistic insight, translational research, and future perspectives in this rapidly evolving field. The goal is to accelerate innovative solutions that can effectively break down the barriers of immune resistance and improve patient outcomes in cancer treatment. Topic editors: Isra Elhussin, Mahmoud Mansour, SIMONE LUBRANO Source: https://www.frontiersin.org/research-topics/72973/multiplex-genome-editing-to-overcome-tumor-immune-evasion