Nanocarrier-based delivery systems and molecular therapeutics for immune modulation: From design to translational application

The convergence of nanotechnology, biomaterials engineering, and molecular therapeutics is reshaping how we design and deliver immunomodulatory interventions. Liposomes, polymeric nanoparticles, dendrimers, micelles, and other engineered carriers are no longer passive transport vehicles. They are now active determinants of immune response, capable of directing antigen presentation, shaping cytokine profiles, and modulating innate and adaptive immunity with unprecedented precision. Despite this progress, a clear mechanistic understanding of how delivery system architecture governs immune outcomes remains incomplete, and translating these platforms into safe, effective therapies continues to pose significant challenges.This Research Topic aims to bring together mechanistic and translational studies that explore how advanced delivery systems and molecular therapeutics can be rationally designed to modulate immune responses for therapeutic benefit. We are particularly interested in research that links carrier design, polymer-drug conjugation strategies, and molecular structure to defined immunological outcomes, such as targeted antigen delivery, controlled cytokine induction, immune cell reprogramming, or tumour microenvironment modulation. By focusing on the interface between delivery science and immunology, this collection seeks to bridge the gap between formulation development and therapeutic efficacy in the context of vaccines and molecular therapeutics.We welcome contributions on the following themes:-Nanocarrier-based platforms (liposomes, nanoparticles, micelles, dendrimers) for vaccine and immunotherapy delivery-Polymer-drug conjugates and biomaterial-mediated immunomodulation-Targeted cancer nanotherapeutics with defined immunological readouts-Nucleic acid therapeutics (mRNA, siRNA, ASOs) and their delivery systems-PROTACs, prodrugs, and click chemistry-based molecular therapeutics with immunomodulatory action-Carbon monoxide-based prodrugs and small-molecule immunomodulators-Transdermal and microbiome-modulating delivery strategies with immune relevance-Quality-by-Design approaches in the development of immunotherapeutic formulations-Biomarkers and immunological signatures predictive of response to nanocarrier-delivered therapeutics-Comparative preclinical evaluations of delivery modalities in vaccine and immunotherapy contextsWe invite original research articles, mechanistic and systematic reviews, and methodological reports. All submissions should provide robust experimental evidence, clear immunological readouts, and well-defined translational relevance. Studies that integrate formulation science, molecular pharmacology, and immunology, particularly those addressing reproducibility, scalability, and clinical applicability, are especially encouraged.By concentrating on the intersection of advanced delivery technologies, molecular therapeutics, and immune modulation, this Research Topic aspires to consolidate current advances and outline future directions for safer, more effective vaccines and immunotherapies. Contributions will help define design principles for next-generation delivery platforms and accelerate the translation of laboratory innovations into clinical solutions. The topic editors declare no conflicts of interest Topic editors: Kantrol Sahu, Phool Chandra, Dr. Balak Das Kurmi Source: https://www.frontiersin.org/research-topics/79855/nanocarrier-based-delivery-systems-and-molecular-therapeutics-for-immune-modulation-from-design-to-translational-application