Nanoformulations at the Interface of Immunopharmacology and Drug Delivery

Immunopharmacology has emerged as a central pillar of modern drug development, underpinning therapeutic strategies for inflammatory, autoimmune, infectious, and degenerative diseases. In parallel, advances in pharmaceutical formulation—particularly nanotechnology-based drug delivery systems—have transformed how drugs interact with biological systems. Increasing evidence demonstrates that nanoformulations are not merely passive carriers but can actively modulate immune responses, influencing drug efficacy, safety, and long-term therapeutic outcomes.Nanoparticles, polymeric nanocarriers, lipid-based systems, and biomaterial-derived formulations can directly interact with immune cells, alter cytokine profiles, modify antigen presentation, and reshape inflammatory microenvironments. These effects may be beneficial, enabling targeted immunomodulation and reduced systemic toxicity, or detrimental, leading to unintended immune activation or suppression. Understanding the bidirectional relationship between nanoformulation design and immune function is therefore critical for the rational development of next-generation therapeutics.This Research Topic aims to bring together cutting-edge research at the intersection of immunopharmacology and nano-enabled drug delivery, highlighting mechanistic insights, translational advances, and emerging challenges. We welcome contributions that explore how physicochemical properties of nanocarriers—such as size, surface charge, composition, and degradability—shape immune recognition, biodistribution, pharmacokinetics, and pharmacodynamics. Particular emphasis will be placed on studies that integrate immunological endpoints into pharmacological evaluation frameworks.Topics of interest include, but are not limited to:- Immunomodulatory effects of nanoformulations beyond the active pharmaceutical ingredient- Nano-enabled delivery of anti-inflammatory, immunosuppressive, and immunostimulatory agents- Nanocarriers as immune adjuvants or tolerogenic platforms- Cytokine modulation, macrophage polarization, and immune cell targeting- Safety, immunotoxicity, and long-term immune consequences of nanomedicines- Translational and regulatory considerations in immunopharmacological nanomedicine developmentThis Research Topic welcomes original research articles, reviews, mini-reviews, and perspectives spanning in vitro, in vivo, and translational studies. By uniting experts from pharmacology, immunology, pharmaceutical sciences, and biomaterials engineering, this collection aims to advance a more integrated understanding of how nanoformulations can be strategically designed to harness—or avoid—immune system interactions. Ultimately, these insights will support the development of safer, more effective, and mechanistically informed therapeutic interventions. Topic editors: Renan Santo, Cássio Santana Meira, Fabio Rocha Formiga Source: https://www.frontiersin.org/research-topics/82724/nanoformulations-at-the-interface-of-immunopharmacology-and-drug-delivery