Nanoparticles and nanostructures in next-generation biosensing and biomedical innovation

Nanobiotechnology is driving a new era in the life sciences, where the intersection of engineered nanomaterials and biology is catalyzing major advances in biomedical devices and diagnostic capabilities. The development and application of nanoparticles and nanostructures—such as quantum dots, nanowires, gold nanoparticles, and nanostructured scaffolds—have enabled unprecedented manipulation and characterization of biological entities at the molecular and cellular levels. This has led to breakthroughs in biosensing technologies, innovative diagnostic and therapeutic approaches, and regenerative medicine. The latest research highlights multifunctional “smart” nanoparticles for highly sensitive biosensors, intelligent drug delivery platforms, and advanced nanodiagnostics, broadening the impact of nanobiotechnology on healthcare and disease management. However, outstanding challenges persist: ensuring safe integration within biological environments, standardizing characterization approaches, navigating regulatory pathways, and assessing long-term health and environmental effects. Continued interdisciplinary exploration is essential to fully realize the potential of these technologies.This Research Topic aims to showcase cutting-edge developments at the intersection of nanotechnology and biomedicine, with a focus on how nanoparticles and nanostructures are engineered, characterized, and applied for biosensing and medical innovation. By emphasizing innovation and translational research, the Topic seeks contributions that advance our mechanistic understanding, technological repertoire, and clinical prospects for nanobiotechnology-driven solutions in biosensing, diagnostics, and therapeutics.To gather further insights in the frontiers of nanobiotechnology, this Research Topic welcomes work that adheres to the section’s scope—covering nanoscale fabrication, characterization, and the functional deployment of nanoparticles and nanostructures for biomedical use. We invite articles addressing, but not limited to, the following themes:- Design, synthesis, and advanced functionalization of nanobiomaterials for biosensing applications- Innovative uses of “smart” nanoparticles and nanostructured surfaces for diagnostics and therapy- Development and deployment of nanobiosensors and nanodiagnostic platforms- Evaluation of nanoscale system impact, nanotoxicology, and device safety- Integration of nanomaterials into organ-on-chip systems and nano-enabled biomedical devices- Regulatory, translational, and ethical dimensions unique to nanobiotechnology- Nanofluidics, smart materials, and next-generation nano-biointerfaces for healthcare Topic editors: Andrea Cusano, Francesca Angelone, Armando Ricciardi, Anna Aliberti Source: https://www.frontiersin.org/research-topics/79743/nanoparticles-and-nanostructures-in-next-generation-biosensing-and-biomedical-innovation