Natural Product-Derived Biologics in Cardiac Repair and Vascular Regeneration

Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, driving urgent demand for effective regenerative strategies. Natural product-derived compounds — including plant-based bioactives, phytochemicals, and botanical extracts — have emerged as a promising class of therapeutic agents, offering diverse mechanisms of action, favorable safety profiles, and strong translational potential for cardiac repair and vascular regeneration.This Research Topic welcomes original research, reviews, systematic reviews, and translational studies examining how natural product-derived compounds contribute to cardiovascular protection, cardiac regeneration, and vascular repair at the molecular, cellular, and systems level.Topics of interest include, but are not limited to:1. Mechanisms of cardiac repair and regeneration-Natural compounds modulating cardiomyocyte survival, proliferation, and differentiation-Stem and progenitor cell activation by botanical or natural bioactives-Extracellular vesicle- and exosome-mediated delivery of natural compounds-Key signaling pathways in myocardial repair (Wnt, Notch, PI3K/Akt, and others)2. Vascular regeneration and remodeling-Natural product modulators of angiogenesis and endothelial function-Anti-inflammatory and antioxidative mechanisms in vascular repair-Effects on vascular smooth muscle cell phenotype and arterial remodeling-Therapeutic targets in atherosclerosis, hypertension, and ischemia-reperfusion injury3. Biologics and bioengineering approaches-Nanoparticle and biomaterial delivery systems for natural compounds-Tissue engineering scaffolds and hydrogel- or patch-based delivery incorporating natural bioactives-Combination strategies integrating natural products with cell or gene-based therapies4. Translational and clinical research-Preclinical models evaluating natural compound efficacy in cardiac and vascular repair-Clinical trials and real-world evidence on natural product-based biologics-Safety, bioavailability, and pharmacokinetic optimization of natural compounds-Omics and systems pharmacology approaches to identify novel therapeutic targets Topic editors: Chuanming Xu, Shan Gao Source: https://www.frontiersin.org/research-topics/82082/natural-product-derived-biologics-in-cardiac-repair-and-vascular-regeneration