Neurobiological mechanisms of adjuvant therapies for personalized stroke rehabilitation: Towards comprehensive recovery, Volume II

Stroke is a major cause of long-term disability worldwide, affecting not only physical function butalso cognition and mental health. People who have had a stroke often face challenges such aslimited mobility and movement, cognitive difficulties, and vision problems, among other effectsthat reduce their quality of life. Although there is ample evidence that rehabilitation strategiescombined with adjuvant treatment improve functional outcomes, the factors that affect individualresponse to these strategies are complex and varied. Personalized stroke rehabilitationapproaches promote the most efficient and cost-effective strategies in the clinic. To personalizestroke rehabilitation, we need to understand the intricate relationship between adjuvanttreatments, stroke rehabilitation, and the underlying neurobiological mechanisms that supportfunctional response. Understanding these mechanisms is crucial for developing comprehensivepersonalized rehabilitation strategies that can successfully integrate adjuvant therapy withstroke rehabilitation to improve function.The purpose of this Research Topic is to investigate the relationship between strokerehabilitation, adjuvant therapies, and the neurobiological mechanisms that contribute tocomprehensive personalized recovery in individuals who have experienced a stroke. Our goal isto explore how adjuvant therapies - such as non-invasive brain stimulation, deep brainstimulation, Hebbian learning, aerobic exercise, mindfulness training, and other such therapies -affect functional stroke outcomes, and to identify the neurobiological mechanisms that facilitatethese outcomes. These mechanisms can include field potentials, functional connectivity, task-related activity, neurotransmitter concentrations, blood flow and other vascular measures, brainmetabolism indices, tissue integrity, blood and other bodily fluid samples, and motor-evokedpotentials, amongst others. By addressing this problem, we hope to identify the most effectiveand personalized combination of adjuvant therapy with stroke rehabilitation that can improveclinical, functional, and behavioral outcomes, ultimately leading to a better quality of life forstroke survivors.We invite authors to submit original research articles, reviews, meta-analyses, clinical trials, andperspectives that offer valuable insights into the connection between stroke rehabilitation,adjuvant therapies, and neurobiological mechanisms. We highly encourage manuscripts thatenhance our understanding of current adjuvant therapies by shedding light on the underlyingmechanisms and exploring their interaction with stroke rehabilitation outcomes. Contributors areinvited to address various themes related to stroke rehabilitation, adjuvant therapies, andneurobiological mechanisms, including, but not limited to: The effects of adjuvant therapies combined with stroke rehabilitation on outcomemeasures, and how they may be explained by the underlying neurobiology. Novel strategies to personalize the combination of adjuvant therapies with strokerehabilitation that are grounded in the participant’s neurobiology. The dosing and timing of adjuvant therapies with stroke rehabilitation in the context ofthe participant’s neurobiology. Developing prediction and triaging models based on the participant’s neurobiology todetermine which combination and rehabilitation may provide the greatest positiveimpact. The effects of adjuvants combined with stroke rehabilitation on the neurobiology. A description of the potential mechanism of adjuvant therapies combined with strokerehabilitation in the context of the neurobiology. Topic editors: Lisa C Krishnamurthy, Lorie Gage Richards, Venkatagiri Krishnamurthy Source: https://www.frontiersin.org/research-topics/78180/neurobiological-mechanisms-of-adjuvant-therapies-for-personalized-stroke-rehabilitation-towards-comprehensive-recovery-volume-ii