Neurogenesis Regulators in Development and Disease

Neurogenesis during brain development is a finely orchestrated process governed by the progressive and specialized divisions of stem and progenitor cells. These cells, localized within distinct domains of the embryonic nervous system, undergo meticulously timed and placed divisions that dictate neurogenic outcomes, such as the quantity and distribution of neurons. This process continues into adulthood, albeit at a reduced rate, and is known as adult neurogenesis, persisting in specific brain regions throughout an individual’s life. Regulation at the molecular level is critical, influencing not only the normal brain function but also playing a role in neurodevelopmental disorders like autism and schizophrenia.This Research Topic aims to explore the intricacies of molecular interactions during neurogenesis and their implications for brain health and disease. It seeks to understand how transcription factors, cytoplasmic regulators, cell surface receptors, and epigenetic modifiers operate and interact during the developmental stages and in the adult brain, particularly in response to injury or in neurodevelopmental disorders. Additionally, the potential of these molecules as therapeutic targets for regenerative medicine or as factors in tumor transformation, such as glioma, is of great interest.To gather further insights into the complexity of neurogenesis, this Research Topic encompasses a broad spectrum of studies focusing on molecular regulation during development and in the adult brain. We welcome articles addressing, but not limited to, the following themes:o     Epigenetic regulation of neurogenesis during developmento     Roles of specific molecular regulators in producing timely output of neuronal subtypeso     Molecular markers for subtypes of stem/progenitor cells in developing and adult braino     Molecular mechanisms that affect adult neurogenesis following brain injuryo     Species-specific regulation of neurogenesiso     Impaired neurogenesis in cortical malformationso     Neurogenesis regulators in glioblastoma progressiono     Glioblastoma stem cell neurogenic potentialThe Research Topic will welcome original research papers, perspectives, and reviews, focusing on the molecular regulation of developmental and/or adult neurogenesis Topic editors: Anton Tonchev, Michael Heide, Tran Tuoc Source: https://www.frontiersin.org/research-topics/67340/neurogenesis-regulators-in-development-and-disease