Neuroinflammation and Brain Fluid Dynamics in Hemorrhagic Stroke: From Bench to Bedside

Hemorrhagic stroke research is undergoing a transformative shift toward understanding the intricate interplay between neuroinflammation and brain fluid dynamics. Historically overshadowed by ischemic stroke, intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage (aSAH) remain among the most devastating cerebrovascular disorders, contributing disproportionately to stroke-related mortality and disability. Beyond the initial bleeding event, a cascade of secondary injuries—including immune activation, blood-brain barrier (BBB) breakdown, and impaired cerebrospinal fluid (CSF) circulation—drives substantial neuronal and glial damage. Recent findings have illuminated the glymphatic system’s critical role in clearing toxic metabolites post-injury, with its disruption emerging as a pivotal determinant of edema, inflammation, and delayed neurodegeneration. Converging evidence suggests that cross-talk between fluid dysregulation and inflammatory signalling underlies many persistent complications, including post-hemorrhagic hydrocephalus and long-term cognitive decline—gaps that remain insufficiently addressed in current neurovascular research paradigms.This Research Topic aims to delineate the mechanistic and translational pathways linking neuroinflammatory processes and glymphatic dysfunction in hemorrhagic stroke. It seeks to clarify how alterations in AQP4 polarization, perivascular signaling, and immune activation contribute to neurovascular injury and neurological recovery. By integrating molecular, cellular, imaging, and clinical evidence, this initiative aspires to identify biomarker signatures of disease progression, refine experimental and computational models of fluid-immune interactions, and promote novel strategies to restore homeostasis following ICH and aSAH. Ultimately, this Research Topic seeks to unify experts across basic and clinical neuroscience to accelerate therapeutic innovation targeting these intertwined pathophysiological systems.To gather further insights into the molecular and physiological determinants of post-hemorrhagic outcomes, the Research Topic welcomes studies spanning preclinical and clinical domains. Contributions may explore, but are not limited to, the following themes:Glymphatic impairment in ICH and aSAH: regulation of aquaporin-4 and perivascular space functionCSF dynamics and post-hemorrhagic hydrocephalus: mechanisms of dysregulation and drainage failureNeuroinflammatory signaling pathways including TLR4, NLRP3, and complement activationBlood-brain barrier disruption and repair: cellular interactions and molecular regulatorsMeningeal lymphatic and dural drainage deficits after hemorrhagic eventsHematoma expansion and coagulation-inflammation coupling mechanismsBiomarker discovery in CSF and blood: inflammatory and neurodegenerative correlatesTranslational modeling of glymphatic and immune dysfunctions in animal and human studiesLong-term neural and cognitive sequelae: white matter injury and neurodegenerationNovel therapeutic and interventional strategies for restoring glymphatic flow, reducing inflammation, or stabilizing the BBB Topic editors: Leonidas Trakolis, Athanasios Petridis Source: https://www.frontiersin.org/research-topics/84226/neuroinflammation-and-brain-fluid-dynamics-in-hemorrhagic-stroke-from-bench-to-bedside